CCND2

Gene Symbol	CCND2
Entrez Gene	894
Alt Symbol	KIAK0002, MPPH3
Species	Human
Gene Type	protein-coding
Description	cyclin D2
Other Description	G1/S-specific cyclin-D2
Swissprots	A8K531 P30279 Q13955 Q5U035
Accessions	AAA51928 AAM54041 EAW88851 P30279 AI055922 AK223577 BAD97297 AK291146 BAF83835 BC010958 AAH10958 BC014357 BC089384 AAH89384 BT019847 AAV38650 BX476896 BX647508 D13639 BAA02802 DQ892845 ABM83771 DQ896091 ABM87090 M90813 AAA51926 X68452 CAA48493 XM_005253813 XP_005253870 NM_001759 NP_001750
Function	Regulatory component of the cyclin D2-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D2/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex (By similarity). {ECO:0000250}.
Subcellular Location	Nucleus {ECO:0000269|PubMed:18827403}. Cytoplasm {ECO:0000269|PubMed:18827403}. Membrane {ECO:0000269|PubMed:18827403}. Note=Cyclin D-CDK4 complexes accumulate at the nuclear membrane and are then translocated into the nucleus through interaction with KIP/CIP family members. {ECO:0000250}.
Top Pathways	PI3K-Akt signaling pathway, Cell cycle, p53 signaling pathway, MicroRNAs in cancer, Focal adhesion

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human CCND2 / Cyclin D2 ELISA Kit (Sandwich ELISA) - LS-F4097 from LifeSpan Bioscience Category ELISA Kit Prices $650.00 Sizes 1 plate Sensitivity 5.9 pg/ml Range 15.63-1000 pg/ml

Mouse/Human/Rat CCND2 / Cyclin D2 ELISA Kit (Cell-Based ELISA) - LS-F1926 from LifeSpan Bioscience Category ELISA Kit Prices $450.00 Sizes 1 plate Range 15.63-1000 pg/ml

Human Cyclin D2 ELISA Kit - abx151223 from Abbexa Category ELISA Kit Sensitivity 5.9 pg/ml Range 15.625 pg/ml - 1000 pg/ml

Cyclin-D2, CCND2, Human, ELISA Kit - E-EL-H2093 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t Sensitivity 0.094 Range 0.156-10ng/mL

Cyclin D2 (CCND2), Human, ELISA Kit - SEA586Hu from ARP American Research Products Category ELISA Kit Prices $650.00 Sizes 96 t Sensitivity 5.7pg/mL Range 15.6-1,000pg/mL

Cyclin D2, Human, ELISA Kit - E01C0484 from ARP American Research Products Category ELISA Kit Prices $535.00, $735.00 Sizes 48 t, 96 t Sensitivity 0.1ng/ml Range 0.5-10 ng/mL,

G1/S-specific cyclin-D2 (CCND2), Human, ELISA Kit - E01G0401 from ARP American Research Products Category ELISA Kit Prices $535.00, $735.00 Sizes 48 t, 96 t

G1/S-specific cyclin-D2, CCND2, Human, ELISA Kit - E0586h from ARP American Research Products Category ELISA Kit Prices $596.00 Sizes 96 t

Cyclin-D2, CCND2, Mouse, ELISA Kit - E-EL-M0382 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t Sensitivity 23.438 Range 39.063-2500pg/mL

Cyclin D2, CCND2, Rat, ELISA Kit - E-EL-R0295 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t Sensitivity 18.75 Range 31.25-2000pg/mL

Cyclin-D2, CCND2, Rabbit, ELISA Kit - E-EL-RB0294 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Cyclin-D2, CCND2, Chicken, ELISA Kit - E-EL-Ch0053 from ARP American Research Products Category ELISA Kit Prices $445.50 Sizes 96 t

Cyclin-D2, CCND2, Porcine, ELISA Kit - E-EL-P0463 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Cyclin-D2, CCND2, Guinea Pig, ELISA Kit - E-EL-GP0748 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t

Cyclin-D2, CCND2, Monkey, ELISA Kit - E-EL-MK0695 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

CCND2 (Human) IP-WB Antibody Pair - H00000894-PW2 from Acris Antibodies Category Antibody Pair Prices $610.00 Sizes 1 set

Human CCND2 ELISA Kit - HC0491 from NeoScientific Category ELISA Kit Prices $495.00 Sizes 96 t

Anserine CCND2 ELISA Kit - AC0491 from NeoScientific Category ELISA Kit Prices $495.00 Sizes 96 t

Cyclin D2 Colorimetric Cell-Based ELISA Kit - CB5187 from Assay Biotechnology Category ELISA Kit Prices $380.00, $760.00, $1,140.00 Sizes 1 kit, 2 kits, 3 kits Range > 5000 Cells

ELISA Kit for Cyclin D2 (CCND2) - SEA586Hu from Uscn Life Science Inc. Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 5.9pg/mL. Range 15.63-1000pg/mL The standard curve concentrations used for the ELISA’s were 1000pg/mL, 500pg/mL, 250pg/mL, 125pg/mL, 62.5pg/mL, 31.25pg/mL, 15.63pg/mL

Human CCND2(Cyclin D2) ELISA Kit - E-EL-H2093 from Elabscience Category ELISA Kit Sensitivity 0.10 ng/mL Range 0.16—10 ng/mL

Human CCND2 (Cyclin-D2) CLIA Kit - E-CL-H1255 from Elabscience Category CLIA Kit Sensitivity 18.75 pg/mL Range Average Recovery (%)

Cyclin D2, ELISA Kit - MBS731925 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Cyclin D2, ELISA Kit - MBS730647 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Cyclin D2, ELISA Kit - MBS728870 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

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