| Gene Symbol | CCND2 |
|---|---|
| Entrez Gene | 894 |
| Alt Symbol | KIAK0002, MPPH3 |
| Species | Human |
| Gene Type | protein-coding |
| Description | cyclin D2 |
| Other Description | G1/S-specific cyclin-D2 |
| Swissprots | A8K531 P30279 Q13955 Q5U035 |
| Accessions | AAA51928 AAM54041 EAW88851 P30279 AI055922 AK223577 BAD97297 AK291146 BAF83835 BC010958 AAH10958 BC014357 BC089384 AAH89384 BT019847 AAV38650 BX476896 BX647508 D13639 BAA02802 DQ892845 ABM83771 DQ896091 ABM87090 M90813 AAA51926 X68452 CAA48493 XM_005253813 XP_005253870 NM_001759 NP_001750 |
| Function | Regulatory component of the cyclin D2-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D2/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex (By similarity). {ECO:0000250}. |
| Subcellular Location | Nucleus {ECO:0000269|PubMed:18827403}. Cytoplasm {ECO:0000269|PubMed:18827403}. Membrane {ECO:0000269|PubMed:18827403}. Note=Cyclin D-CDK4 complexes accumulate at the nuclear membrane and are then translocated into the nucleus through interaction with KIP/CIP family members. {ECO:0000250}. |
| Top Pathways | PI3K-Akt signaling pathway, Cell cycle, p53 signaling pathway, MicroRNAs in cancer, Focal adhesion |