CCND2

Gene Symbol CCND2
Entrez Gene 894
Alt Symbol KIAK0002, MPPH3
Species Human
Gene Type protein-coding
Description cyclin D2
Other Description G1/S-specific cyclin-D2
Swissprots A8K531 P30279 Q13955 Q5U035
Accessions AAA51928 AAM54041 EAW88851 P30279 AI055922 AK223577 BAD97297 AK291146 BAF83835 BC010958 AAH10958 BC014357 BC089384 AAH89384 BT019847 AAV38650 BX476896 BX647508 D13639 BAA02802 DQ892845 ABM83771 DQ896091 ABM87090 M90813 AAA51926 X68452 CAA48493 XM_005253813 XP_005253870 NM_001759 NP_001750
Function Regulatory component of the cyclin D2-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D2/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex (By similarity). {ECO:0000250}.
Subcellular Location Nucleus {ECO:0000269|PubMed:18827403}. Cytoplasm {ECO:0000269|PubMed:18827403}. Membrane {ECO:0000269|PubMed:18827403}. Note=Cyclin D-CDK4 complexes accumulate at the nuclear membrane and are then translocated into the nucleus through interaction with KIP/CIP family members. {ECO:0000250}.
Top Pathways PI3K-Akt signaling pathway, Cell cycle, p53 signaling pathway, MicroRNAs in cancer, Focal adhesion

CCND2-Over-expression-Lysate - LY12265a from Abgent, a WuXi AppTec company

Category Cell Lysate
Prices $325.00
Sizes 100 µg
Western blot analysis of his-tag CCND2 (arrow) using his tag antibody. 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the CCND2 gene

CCND2 293T Cell Transient Overexpression Lysate(Denatured) - H00000894-T01 from Acris Antibodies

Category Cell Lysate
Prices $320.00
Sizes 100 µl

CCND2 293 Cell Lysate - 409249 from ABBIOTEC

Category Cell Lysate
Prices $392.00
Sizes 100 µg

Cyclin D2 Overexpression Lysate (Denatured) - H00000894-T01 from Novus Biologicals

Category Cell Lysate
Prices $279.00
Sizes 100 µl
CCND2 transfected lysate.

Cyclin D2 Overexpression Lysate (Native) - NBL1-08872 from Novus Biologicals

Category Cell Lysate
Prices $329.00
Sizes 100 µg
Western Blot: Cyclin D2 Overexpression Lysate (Adult Normal) [NBL1-08872] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for Cyclin D2.

cyclin D2 (h): 293T Lysate - sc-111616 from Santa Cruz Biotechnology

Category Cell Lysate
Prices $205.00
Sizes 100 µg/200 µl
Species Human

CCND2 Over-expression Lysate Product - GWB-A6DC40 from Genway Biotech

Category Cell Lysate
Prices $346.00
Sizes 100 µg
Species Human

Cyclin D2 Overexpression Lysate (Denatured) - H00000894-T02 from Novus Biologicals

Category Cell Lysate
Prices $299.00
Sizes 100 µl

Panoply™ Human CCND2 Knockdown Stable Cell Line - CSC-DC002647 from Creative biogene

Category Cell Line
Species Human
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