CCND2

Gene Symbol	CCND2
Entrez Gene	894
Alt Symbol	KIAK0002, MPPH3
Species	Human
Gene Type	protein-coding
Description	cyclin D2
Other Description	G1/S-specific cyclin-D2
Swissprots	A8K531 P30279 Q13955 Q5U035
Accessions	AAA51928 AAM54041 EAW88851 P30279 AI055922 AK223577 BAD97297 AK291146 BAF83835 BC010958 AAH10958 BC014357 BC089384 AAH89384 BT019847 AAV38650 BX476896 BX647508 D13639 BAA02802 DQ892845 ABM83771 DQ896091 ABM87090 M90813 AAA51926 X68452 CAA48493 XM_005253813 XP_005253870 NM_001759 NP_001750
Function	Regulatory component of the cyclin D2-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D2/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex (By similarity). {ECO:0000250}.
Subcellular Location	Nucleus {ECO:0000269|PubMed:18827403}. Cytoplasm {ECO:0000269|PubMed:18827403}. Membrane {ECO:0000269|PubMed:18827403}. Note=Cyclin D-CDK4 complexes accumulate at the nuclear membrane and are then translocated into the nucleus through interaction with KIP/CIP family members. {ECO:0000250}.
Top Pathways	PI3K-Akt signaling pathway, Cell cycle, p53 signaling pathway, MicroRNAs in cancer, Focal adhesion

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Cyclin D2 peptide - ab109274 from Abcam Category Peptide Prices $181.00 Sizes 100 µg

Human Cyclin D2 full length protein - ab116405 from Abcam Category Protein Source E. coli Species Human

CCND2 / Cyclin D2 Antibody Blocking Peptide - LS-E3268 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human Cyclin D2 Protein - H00000894-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Cyclin D2 Partial Recombinant Protein - H00000894-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human Cyclin D2 Protein - NBP1-78841 from Novus Biologicals Category Protein Prices $269.00, $729.00 Sizes 100 µg, 500 µg Source E.coli Species Human

CCND2-Antibody-N-term-Blocking-Peptide - BP14421a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Human CCND2 protein - orb168063 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 5 μg, 20 μg Source E. coli

Cyclin D2 peptide - orb72591 from Biorbyt Category Peptide Prices $238.00 Sizes 500 µg

CCND2 protein (His tag) - 80R-2084 from Fitzgerald Category Protein Prices $270.00 Sizes 100 µg Source E.coli

Human Cyclin D2 Protein - abx066198 from Abbexa Category Protein Source E.coli Species Human

Cyclin D2 (1-289, His-tag) - AR50167PU-N from Acris Antibodies Category Protein Prices $790.00 Sizes 500 µg Source E. coli Species Human

Cyclin D2 (1-289, His-tag) - AR50167PU-S from Acris Antibodies Category Protein Prices $340.00 Sizes 100 µg Source E. coli Species Human

Cyclin D2 - H00000894-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

Cyclin D2 - H00000894-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

Cyclin D2 - H00000894-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

Cyclin D2 - H00000894-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

Recombinant Human Cyclin D2 - 230-00622-10 from RayBiotech Category Protein Prices $107.00 Sizes 10 µg Source Escherichia coli (E.coli) Species Human

Recombinant Human Cyclin D2 - 230-00622-50 from RayBiotech Category Protein Prices $217.00 Sizes 50 µg Source Escherichia coli (E.coli) Species Human

Recombinant Human Cyclin D2 - 230-00622-100 from RayBiotech Category Protein Prices $326.00 Sizes 100 µg Source Escherichia coli (E.coli) Species Human

Cyclin D2, Human Recombinant - 228-12833-1 from RayBiotech Category Protein Prices $118.00 Sizes 1 µg Species Human

Recombinant Cyclin D2 Human - 228-12833-2 from RayBiotech Category Protein Prices $189.00 Sizes 2 µg Source Escherichia Coli. Species Human

Recombinant Cyclin D2 Human - 228-12833-3 from RayBiotech Category Protein Prices $2,880.00 Sizes 3 µg Source Escherichia Coli. Species Human

CCND2, 1-289 aa, Human, His tag, E.coli - 01-P1342 from ARP American Research Products Category Protein Prices $179.00, $369.00, $849.00 Sizes 20 µg, 100 µg, 500 µg Species Human

CCND2 fusion protein - Ag1377 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

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