CCDC109B

Gene Symbol CCDC109B
Entrez Gene 55013
Alt Symbol MCUb
Species Human
Gene Type protein-coding
Description coiled-coil domain containing 109B
Other Description calcium uniporter regulatory subunit MCUb, mitochondrial|coiled-coil domain-containing protein 109B|mitochondrial calcium uniporter regulatory subunit MCUb
Swissprots Q9NWR8 Q6IAC1 A8K4Y3
Accessions EAX06242 EAX06243 Q9NWR8 AK000654 BAA91309 AK095936 AK291098 BAF83787 AK311030 AL832311 BC002633 AAH02633 BM830891 CN427680 CR457234 CAG33515 HQ447337 ADQ31823 XM_006714246 XP_006714309 NM_017918 NP_060388
Function Negatively regulates the activity of MCU, the mitochondrial inner membrane calcium uniporter, and thereby modulates calcium uptake into the mitochondrion. Does not form functional calcium channels by itself. Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates cell bioenergetics, cytoplasmic calcium signals and activation of cell death pathways. {ECO:0000250|UniProtKB:Q810S1}.
Subcellular Location Mitochondrion inner membrane {ECO:0000269|PubMed:24231807}; Multi-pass membrane protein {ECO:0000269|PubMed:24231807}.

CCDC109B (C-12) - sc-163982 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
CCDC109B (C-12): sc-163982. Western blot analysis of CCDC109B expression in PANC-1 (A), A549 (B), HeLa (C), Jurkat (D) and K-562 (E) whole cell lysates.

CCDC109B (F-12) - sc-163983 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

CCDC109B (S-15) - sc-163985 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-CCDC109B antibody - ab151038 from Abcam

Prices $443.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of Paraffin-Embedded Human tonsil tissue, labeling CCDC109B with ab151038 at 1/1000 dilution.

Anti-CCDC109B antibody - C-terminal - ab170715 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-CCDC109B antibody - C-terminal (ab170715) at 1/100 dilution + A549 cell lysate at 35 µg

Anti-CCDC109B Antibody (aa291-320, AP) - LS-C252791 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-CCDC109B Antibody (aa291-320, Azide-free, HRP) - LS-C252795 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-CCDC109B Antibody (aa291-320, Biotin) - LS-C252792 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-CCDC109B Antibody (aa291-320, APC) - LS-C252793 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-CCDC109B Antibody (aa291-320, PE) - LS-C252796 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-CCDC109B Antibody (aa291-320, FITC) - LS-C252794 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-CCDC109B Antibody (aa298-328) - LS-C319912 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-CCDC109B Antibody (aa291-320) - LS-C156906 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
C109B Antibody western blot of A549 cell line lysates (35 ug/lane). The C109B antibody detected the C109B protein (arrow).

CCDC109B Antibody - NBP2-14657 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

ANTI-C109B (C-TERM) antibody produced in rabbit - SAB1302418 from Sigma-Aldrich

Prices $326.50
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-CCDC109B antibody produced in rabbit - HPA048776 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-CCDC109B:<B>Cat. No. HPA048776</B>: Immunohistochemical staining of human tonsil shows strong cytoplasmic positivity in subset of non-germinal center cells.

C109B-Antibody-C-term - AP12355b from Abgent, a WuXi AppTec company

Prices $99.00, $295.00
Sizes 80 µl, 400 µl
Host Rabbit
Clonality Polyclonal
Western blot analysis of lysates from Daudi, HL-60 cell line (from left to right), using C109B Antibody (C-term)(Cat. #AP12355b). AP12355b was diluted at 1:1000 at each lane. A goat anti-rabbit IgG H&L(HRP) at 1:5000 dilution was used as the secondary antibody. Lysates at 35ug per lane.

C109B Antibody - C-terminal region (OAAB08618) - OAAB08618 from Aviva Systems Biology

Prices $289.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal

Anti -C109B, CT (CCDC109B, Coiled-coil domain-containing protein 109B) - 032634 from USBiological Life Science

Host Rabbit
Clonality Polyclonal

Anti -C109B, CT (CCDC109B, Coiled-coil domain-containing protein 109B) (AP) - 032634-AP from USBiological Life Science

Host Rabbit
Clonality Polyclonal

Anti -C109B, CT (CCDC109B, Coiled-coil domain-containing protein 109B) (APC) - 032634-APC from USBiological Life Science

Host Rabbit
Clonality Polyclonal

Anti -C109B, CT (CCDC109B, Coiled-coil domain-containing protein 109B) (Biotin) - 032634-Biotin from USBiological Life Science

Host Rabbit
Clonality Polyclonal

Anti -C109B, CT (CCDC109B, Coiled-coil domain-containing protein 109B) (FITC) - 032634-FITC from USBiological Life Science

Host Rabbit
Clonality Polyclonal

Anti -C109B, CT (CCDC109B, Coiled-coil domain-containing protein 109B) (PE) - 032634-PE from USBiological Life Science

Host Rabbit
Clonality Polyclonal
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