CCDC109B
| Gene Symbol | CCDC109B |
|---|---|
| Entrez Gene | 55013 |
| Alt Symbol | MCUb |
| Species | Human |
| Gene Type | protein-coding |
| Description | coiled-coil domain containing 109B |
| Other Description | calcium uniporter regulatory subunit MCUb, mitochondrial|coiled-coil domain-containing protein 109B|mitochondrial calcium uniporter regulatory subunit MCUb |
| Swissprots | Q9NWR8 Q6IAC1 A8K4Y3 |
| Accessions | EAX06242 EAX06243 Q9NWR8 AK000654 BAA91309 AK095936 AK291098 BAF83787 AK311030 AL832311 BC002633 AAH02633 BM830891 CN427680 CR457234 CAG33515 HQ447337 ADQ31823 XM_006714246 XP_006714309 NM_017918 NP_060388 |
| Function | Negatively regulates the activity of MCU, the mitochondrial inner membrane calcium uniporter, and thereby modulates calcium uptake into the mitochondrion. Does not form functional calcium channels by itself. Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates cell bioenergetics, cytoplasmic calcium signals and activation of cell death pathways. {ECO:0000250|UniProtKB:Q810S1}. |
| Subcellular Location | Mitochondrion inner membrane {ECO:0000269|PubMed:24231807}; Multi-pass membrane protein {ECO:0000269|PubMed:24231807}. |
CCDC109B Antibody Blocking Peptide - LS-E1608 from LifeSpan Bioscience
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C109B-Antibody-C-term-Blocking-peptide - BP12355b from Abgent, a WuXi AppTec company
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CCDC109B fusion protein - ag14225 from Proteintech Group
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CCDC109B fusion protein - ag16928 from Proteintech Group
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CCDC109B Recombinant Protein Antigen - NBP2-14657PEP from Novus Biologicals
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CCDC109B Peptide, Human - M34GP02462H from Creative Peptides
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Coiled-coil domain-containing protein 109B (CCDC109B), Recombinant Protein - MBS7010927 from MyBioSource
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