| Gene Symbol |
Mag
|
| Entrez Gene |
17136
|
| Alt Symbol |
Gma, siglec-4a
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
myelin-associated glycoprotein
|
| Other Description |
-
|
| Swissprots |
P16880 P20917
|
| Accessions |
AAA91743 EDL23978 P20917 AK003029 BAB22519 AK045564 BC101944 AAI01945 BC103521 AAI03522 BC103522 AAI03523 BC103523 AAI03524 M31811 AAA39487 X07849 CAA30696 XM_006539590 XP_006539653 XM_006539591 XP_006539654 XM_011250438 XP_011248740 XM_011250439 XP_011248741 XM_011250440 XP_011248742 XM_011250441 XP_011248743 NM_010758 NP_034888
|
| Function |
Adhesion molecule in postnatal neural development that mediates sialic-acid dependent cell-cell interactions between neuronal and myelinating cells. Preferentially binds to alpha-2,3- linked sialic acid. Isoform L-MAG is critical for the formation of myelin in the CNS, whereas isoform S-MAG is sufficient to maintain the integrity of myelin in PNS. {ECO:0000269|PubMed:10625334}.
|
| Subcellular Location |
Membrane; Single-pass type I membrane protein.
|
| Tissue Specificity |
Expressed by myelinating glial cells in the central and peripheral nervous system. Detected in oligodendrocyte processes before formation of compact myelin. Restricted to the periaxonal space after myelination. Isoform S-MAG is the predominant isoform in CNS and PNS of the adult. {ECO:0000269|PubMed:10625334, ECO:0000269|PubMed:1716323}.
|
| Top Pathways |
Cell adhesion molecules (CAMs)
|