Gene Symbol | Mag |
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Entrez Gene | 17136 |
Alt Symbol | Gma, siglec-4a |
Species | Mouse |
Gene Type | protein-coding |
Description | myelin-associated glycoprotein |
Other Description | - |
Swissprots | P16880 P20917 |
Accessions | AAA91743 EDL23978 P20917 AK003029 BAB22519 AK045564 BC101944 AAI01945 BC103521 AAI03522 BC103522 AAI03523 BC103523 AAI03524 M31811 AAA39487 X07849 CAA30696 XM_006539590 XP_006539653 XM_006539591 XP_006539654 XM_011250438 XP_011248740 XM_011250439 XP_011248741 XM_011250440 XP_011248742 XM_011250441 XP_011248743 NM_010758 NP_034888 |
Function | Adhesion molecule in postnatal neural development that mediates sialic-acid dependent cell-cell interactions between neuronal and myelinating cells. Preferentially binds to alpha-2,3- linked sialic acid. Isoform L-MAG is critical for the formation of myelin in the CNS, whereas isoform S-MAG is sufficient to maintain the integrity of myelin in PNS. {ECO:0000269|PubMed:10625334}. |
Subcellular Location | Membrane; Single-pass type I membrane protein. |
Tissue Specificity | Expressed by myelinating glial cells in the central and peripheral nervous system. Detected in oligodendrocyte processes before formation of compact myelin. Restricted to the periaxonal space after myelination. Isoform S-MAG is the predominant isoform in CNS and PNS of the adult. {ECO:0000269|PubMed:10625334, ECO:0000269|PubMed:1716323}. |
Top Pathways | Cell adhesion molecules (CAMs) |
MAG CRISPR/Cas9 KO Plasmid (m) - sc-421535 from Santa Cruz Biotechnology
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MAG HDR Plasmid (m) - sc-421535-HDR from Santa Cruz Biotechnology
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MAG Double Nickase Plasmid (m) - sc-421535-NIC from Santa Cruz Biotechnology
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MAG Double Nickase Plasmid (m2) - sc-421535-NIC-2 from Santa Cruz Biotechnology
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MAG CRISPR Activation Plasmid (m) - sc-421535-ACT from Santa Cruz Biotechnology
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MAG CRISPR Activation Plasmid (m2) - sc-421535-ACT-2 from Santa Cruz Biotechnology
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MAG Lentiviral Activation Particles (m) - sc-421535-LAC from Santa Cruz Biotechnology
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MAG Lentiviral Activation Particles (m2) - sc-421535-LAC-2 from Santa Cruz Biotechnology
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MAG siRNA (m) - sc-35842 from Santa Cruz Biotechnology
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MAG shRNA Plasmid (m) - sc-35842-SH from Santa Cruz Biotechnology
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MAG shRNA (m) Lentiviral Particles - sc-35842-V from Santa Cruz Biotechnology
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CompoZr® Knockout ZFN Kit - CKOZFN35163 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND35163 from Sigma-Aldrich
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MAG siRNA (Mouse) - CRM2444 from Cohesion Biosciences
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shRNA set against Mouse Mag(NM_010758.2) - SHH170525 from Creative biogene
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Mouse MAG siRNA - orb281920 from Biorbyt
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MAG shRNA Plasmid (Mouse) - CHM2444 from Cohesion Biosciences
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MAG miRNA 3'UTR clone - MiUTR1M-06878 from Creative biogene
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