| Gene Symbol | Mag |
|---|---|
| Entrez Gene | 17136 |
| Alt Symbol | Gma, siglec-4a |
| Species | Mouse |
| Gene Type | protein-coding |
| Description | myelin-associated glycoprotein |
| Other Description | - |
| Swissprots | P16880 P20917 |
| Accessions | AAA91743 EDL23978 P20917 AK003029 BAB22519 AK045564 BC101944 AAI01945 BC103521 AAI03522 BC103522 AAI03523 BC103523 AAI03524 M31811 AAA39487 X07849 CAA30696 XM_006539590 XP_006539653 XM_006539591 XP_006539654 XM_011250438 XP_011248740 XM_011250439 XP_011248741 XM_011250440 XP_011248742 XM_011250441 XP_011248743 NM_010758 NP_034888 |
| Function | Adhesion molecule in postnatal neural development that mediates sialic-acid dependent cell-cell interactions between neuronal and myelinating cells. Preferentially binds to alpha-2,3- linked sialic acid. Isoform L-MAG is critical for the formation of myelin in the CNS, whereas isoform S-MAG is sufficient to maintain the integrity of myelin in PNS. {ECO:0000269|PubMed:10625334}. |
| Subcellular Location | Membrane; Single-pass type I membrane protein. |
| Tissue Specificity | Expressed by myelinating glial cells in the central and peripheral nervous system. Detected in oligodendrocyte processes before formation of compact myelin. Restricted to the periaxonal space after myelination. Isoform S-MAG is the predominant isoform in CNS and PNS of the adult. {ECO:0000269|PubMed:10625334, ECO:0000269|PubMed:1716323}. |
| Top Pathways | Cell adhesion molecules (CAMs) |