CYP1A2

Gene Symbol CYP1A2
Entrez Gene 1544
Alt Symbol CP12, P3-450, P450(PA)
Species Human
Gene Type protein-coding
Description cytochrome P450, family 1, subfamily A, polypeptide 2
Other Description CYPIA2|P450 form 4|aryl hydrocarbon hydroxylase|cytochrome P(3)450|cytochrome P450 1A2|cytochrome P450 4|cytochrome P450, subfamily I (aromatic compound-inducible), polypeptide 2|cytochrome P450-P3|dioxin-inducible P3-450|flavoprotein-linked monooxygenase|microsomal monooxygenase|xenobiotic monooxygenase
Swissprots Q16754 Q9UK49 Q6NWU5 Q9BXX7 P05177
Accessions AAA35738 AAA52163 AAK25728 AAY26399 EAW99313 P05177 AF182274 AAF13599 BC067424 AAH67424 BC067425 AAH67425 BC067426 AAH67426 BC067427 AAH67427 BC067428 AAH67428 BC067429 AAH67429 M12078 AAA52154 M55053 AAA52146 Z00036 CAA77335 NM_000761 NP_000752
Function Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Most active in catalyzing 2-hydroxylation. Caffeine is metabolized primarily by cytochrome CYP1A2 in the liver through an initial N3-demethylation. Also acts in the metabolism of aflatoxin B1 and acetaminophen. Participates in the bioactivation of carcinogenic aromatic and heterocyclic amines. Catalizes the N-hydroxylation of heterocyclic amines and the O- deethylation of phenacetin. {ECO:0000269|PubMed:14725854}.
Subcellular Location Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
Tissue Specificity Liver.
Top Pathways Chemical carcinogenesis, Steroid hormone biosynthesis, Drug metabolism - cytochrome P450, Metabolism of xenobiotics by cytochrome P450, Tryptophan metabolism

CYP1A2 293T Cell Transient Overexpression Lysate(Denatured) - H00001544-T01 from Acris Antibodies

Category Cell Lysate
Prices $320.00
Sizes 100 µl

CYP1A2 overexpression lysate - LY424529 from Acris Antibodies

Category Cell Lysate
Prices $280.00
Sizes 100 µg

Cytochrome P450 1A2 Overexpression Lysate (Denatured) - H00001544-T01 from Novus Biologicals

Category Cell Lysate
Prices $279.00
Sizes 100 µl
CYP1A2 transfected lysate.

Cytochrome P450 1A2 Overexpression Lysate (Native) - NBP2-10707 from Novus Biologicals

Category Cell Lysate
Prices $329.00
Sizes 100 µg
Western Blot: Cytochrome P450 1A2 Overexpression Lysate (Adult Normal) [NBP2-10707] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for Cytochrome P450 1A2.

Cytochrome P450 1A2 Overexpression Lysate (Denatured) - H00001544-T02 from Novus Biologicals

Category Cell Lysate
Prices $299.00
Sizes 100 µl

Panoply™ Human CYP1A2 Knockdown Stable Cell Line - CSC-DC003941 from Creative biogene

Category Cell Line
Species Human
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