CYP1A2

Gene Symbol CYP1A2
Entrez Gene 1544
Alt Symbol CP12, P3-450, P450(PA)
Species Human
Gene Type protein-coding
Description cytochrome P450, family 1, subfamily A, polypeptide 2
Other Description CYPIA2|P450 form 4|aryl hydrocarbon hydroxylase|cytochrome P(3)450|cytochrome P450 1A2|cytochrome P450 4|cytochrome P450, subfamily I (aromatic compound-inducible), polypeptide 2|cytochrome P450-P3|dioxin-inducible P3-450|flavoprotein-linked monooxygenase|microsomal monooxygenase|xenobiotic monooxygenase
Swissprots Q16754 Q9UK49 Q6NWU5 Q9BXX7 P05177
Accessions AAA35738 AAA52163 AAK25728 AAY26399 EAW99313 P05177 AF182274 AAF13599 BC067424 AAH67424 BC067425 AAH67425 BC067426 AAH67426 BC067427 AAH67427 BC067428 AAH67428 BC067429 AAH67429 M12078 AAA52154 M55053 AAA52146 Z00036 CAA77335 NM_000761 NP_000752
Function Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Most active in catalyzing 2-hydroxylation. Caffeine is metabolized primarily by cytochrome CYP1A2 in the liver through an initial N3-demethylation. Also acts in the metabolism of aflatoxin B1 and acetaminophen. Participates in the bioactivation of carcinogenic aromatic and heterocyclic amines. Catalizes the N-hydroxylation of heterocyclic amines and the O- deethylation of phenacetin. {ECO:0000269|PubMed:14725854}.
Subcellular Location Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
Tissue Specificity Liver.
Top Pathways Chemical carcinogenesis, Steroid hormone biosynthesis, Drug metabolism - cytochrome P450, Metabolism of xenobiotics by cytochrome P450, Tryptophan metabolism

CYP1A2 CRISPR/Cas9 KO Plasmid (h) - sc-401178 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

CYP1A2 HDR Plasmid (h) - sc-401178-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CYP1A2 Double Nickase Plasmid (h) - sc-401178-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CYP1A2 Double Nickase Plasmid (h2) - sc-401178-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CYP1A2 CRISPR Activation Plasmid (h) - sc-401178-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

CYP1A2 CRISPR Activation Plasmid (h2) - sc-401178-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

CYP1A2 Lentiviral Activation Particles (h) - sc-401178-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CYP1A2 Lentiviral Activation Particles (h2) - sc-401178-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CYP1A2 siRNA (h) - sc-41485 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

CYP1A2 shRNA Plasmid (h) - sc-41485-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

CYP1A2 shRNA (h) Lentiviral Particles - sc-41485-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Cytochrome P450 1A2 RNAi - H00001544-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU030071 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

MISSION® esiRNA - EHU019351 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

MISSION® esiRNA - EHU001461 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CYP1A2 siRNA (Human) - CRH1091 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

CYP1A2 - MBS8205216 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

CYP1A2 CRISPR/Cas9 KO Plasmid (h2) - sc-401178-KO-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

CYP1A2 HDR Plasmid (h2) - sc-401178-HDR-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

shRNA set against Human CYP1A2 (NM_000761.3) - SHH272877 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human CYP1A2(NM_000761.3) - SHG215601 from Creative biogene

Category siRNA
Species Reactivities Human

Human CYP1A2 siRNA - orb261593 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

CYP1A2 shRNA Plasmid (Human) - CHH1091 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

CYP1A2 miRNA 3'UTR clone - MiUTR1H-02611 from Creative biogene

Species Reactivities Human
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