| Gene Symbol |
CYP1A2
|
| Entrez Gene |
1544
|
| Alt Symbol |
CP12, P3-450, P450(PA)
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
cytochrome P450, family 1, subfamily A, polypeptide 2
|
| Other Description |
CYPIA2|P450 form 4|aryl hydrocarbon hydroxylase|cytochrome P(3)450|cytochrome P450 1A2|cytochrome P450 4|cytochrome P450, subfamily I (aromatic compound-inducible), polypeptide 2|cytochrome P450-P3|dioxin-inducible P3-450|flavoprotein-linked monooxygenase|microsomal monooxygenase|xenobiotic monooxygenase
|
| Swissprots |
Q16754 Q9UK49 Q6NWU5 Q9BXX7 P05177
|
| Accessions |
AAA35738 AAA52163 AAK25728 AAY26399 EAW99313 P05177 AF182274 AAF13599 BC067424 AAH67424 BC067425 AAH67425 BC067426 AAH67426 BC067427 AAH67427 BC067428 AAH67428 BC067429 AAH67429 M12078 AAA52154 M55053 AAA52146 Z00036 CAA77335 NM_000761 NP_000752
|
| Function |
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Most active in catalyzing 2-hydroxylation. Caffeine is metabolized primarily by cytochrome CYP1A2 in the liver through an initial N3-demethylation. Also acts in the metabolism of aflatoxin B1 and acetaminophen. Participates in the bioactivation of carcinogenic aromatic and heterocyclic amines. Catalizes the N-hydroxylation of heterocyclic amines and the O- deethylation of phenacetin. {ECO:0000269|PubMed:14725854}.
|
| Subcellular Location |
Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
|
| Tissue Specificity |
Liver.
|
| Top Pathways |
Chemical carcinogenesis, Steroid hormone biosynthesis, Drug metabolism - cytochrome P450, Metabolism of xenobiotics by cytochrome P450, Tryptophan metabolism
|