CYP1A2

Gene Symbol	CYP1A2
Entrez Gene	1544
Alt Symbol	CP12, P3-450, P450(PA)
Species	Human
Gene Type	protein-coding
Description	cytochrome P450, family 1, subfamily A, polypeptide 2
Other Description	CYPIA2|P450 form 4|aryl hydrocarbon hydroxylase|cytochrome P(3)450|cytochrome P450 1A2|cytochrome P450 4|cytochrome P450, subfamily I (aromatic compound-inducible), polypeptide 2|cytochrome P450-P3|dioxin-inducible P3-450|flavoprotein-linked monooxygenase|microsomal monooxygenase|xenobiotic monooxygenase
Swissprots	Q16754 Q9UK49 Q6NWU5 Q9BXX7 P05177
Accessions	AAA35738 AAA52163 AAK25728 AAY26399 EAW99313 P05177 AF182274 AAF13599 BC067424 AAH67424 BC067425 AAH67425 BC067426 AAH67426 BC067427 AAH67427 BC067428 AAH67428 BC067429 AAH67429 M12078 AAA52154 M55053 AAA52146 Z00036 CAA77335 NM_000761 NP_000752
Function	Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Most active in catalyzing 2-hydroxylation. Caffeine is metabolized primarily by cytochrome CYP1A2 in the liver through an initial N3-demethylation. Also acts in the metabolism of aflatoxin B1 and acetaminophen. Participates in the bioactivation of carcinogenic aromatic and heterocyclic amines. Catalizes the N-hydroxylation of heterocyclic amines and the O- deethylation of phenacetin. {ECO:0000269|PubMed:14725854}.
Subcellular Location	Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
Tissue Specificity	Liver.
Top Pathways	Chemical carcinogenesis, Steroid hormone biosynthesis, Drug metabolism - cytochrome P450, Metabolism of xenobiotics by cytochrome P450, Tryptophan metabolism

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Cytochrome P450 1A2 full length protein - ab158245 from Abcam Category Protein Source Wheat germ Species Human

Human Cytochrome P450 1A2 protein fragment - ab114370 from Abcam Category Protein Source Wheat germ Species Human

CYP1A2 Antibody Blocking Peptide - LS-E921 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CYP1A2 Antibody Blocking Peptide - LS-E27778 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human Cytochrome P450 1A2 Protein - H00001544-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human Cytochrome P450 1A2 Protein - H00001544-P01 from Novus Biologicals Category Protein Prices $319.00 Sizes 2 µg Source Wheat Germ Species Human

CYP1A2-Antibody-Center-Blocking-peptide - BP11325c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Cyp1a2 Immunizing peptide - orb65734 from Biorbyt Category Peptide Prices $247.00 Sizes 100 μg Species Human, Mouse, Rat

Human Cytochrome P450 1A2 Protein - abx066251 from Abbexa Category Protein Source E.coli Species Human

CYP1A2 - H00001544-P01 from Acris Antibodies Category Protein Prices $340.00 Sizes 2 µg Species Human

CYP1A2 - H00001544-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

CYP1A2 - H00001544-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

Cytochrome P450 1A2 (CYP1A2), Human - 20-8735 from ARP American Research Products Category Protein Prices $449.00 Sizes 50 µg Source E.coli Species Human

Recombinant Human CYP1A2 - CYP1A2-27559TH from Creative Biomart Category Protein Source Wheat germ

Recombinant Human CYP1A2, MYC/DDK-tagged - CYP1A2-150H from Creative Biomart Category Protein Source HEK293 Cells Species Human

Recombinant Human CYP1A2 - CYP1A2-121H from Creative Biomart Category Protein Source Microsomes prepared from insect cells that were infected with baculovirus containing the cDNA for human CYP1A2 and rabbit cytochrome P450 reductase

Recombinant Human CYP1A2 - CYP1A2-551H from Creative Biomart Category Protein Source baculovirus infected insect cells Species Human

Recombinant Cytochrome P450 1A2 (CYP1A2) - RPD294Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

Recombinant Cytochrome P450 1A2 (CYP1A2) - RPD294Hu02 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

Recombinant Cytochrome P450 1A2 (CYP1A2) - RPD294Ra01 from Uscn Life Science Inc. Category Protein Source E.coli Species Rat

Recombinant Cytochrome P450 1A2 (CYP1A2) - RPD294Hu01 from Cloud-clone Category Protein Source E.coli Species Human

Recombinant Cytochrome P450 1A2 (CYP1A2) - RPD294Hu02 from Cloud-clone Category Protein Source E.coli Species Human

Recombinant Human Cytochrome P450 1A2(CYP1A2) - CSB-YP006396HU CSB-EP006396HU CSB-BP006396HU CSB-MP006396HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

EZCyp™ Active Human Cytochrome P450 1A2 - 7876-10 from Biovision Category Protein Prices $125.00 Sizes 10 mg Source Pichia pastoris Species Human

EZCyp™ Active Human Cytochrome P450 1A2 - 7876-50 from Biovision Category Protein Prices $475.00 Sizes 50 mg Source Pichia pastoris Species Human

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