PIK3R1

Gene Symbol	PIK3R1
Entrez Gene	5295
Alt Symbol	AGM7, GRB1, IMD36, p85, p85-ALPHA
Species	Human
Gene Type	protein-coding
Description	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
Other Description	PI3-kinase subunit p85-alpha|PI3K regulatory subunit alpha|phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha|phosphatidylinositol 3-kinase regulatory subunit alpha|phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha)|phosphatidylinositol 3-kinase-associated p-85 alpha|phosphoinositide-3-kinase regulatory subunit|ptdIns-3-kinase regulatory subunit alpha
Swissprots	B3KT19 Q8N1C5 Q4VBZ7 E7EX19 P27986 Q15747 D3DWA0 Q53EM6 Q8IXA2
Accessions	EAW51311 EAW51312 EAW51313 P27986 AF279367 AAO15359 AI124626 AI334281 AK000121 AK094785 BAG52931 AK126345 BAG54309 AK223613 BAD97333 AK294919 BAH11924 AK299743 BAH13115 AW630519 BC030815 AAH30815 BC094795 AAH94795 BE888150 BQ723333 CA427864 CB216668 CT003423 DA487709 HQ447692 ADQ32177 JX133164 AFP86291 JX133165 AFP86292 M61906 U49349 AAB04140 XM_005248542 XP_005248599 XM_011543493 XP_011541795 NM_001242466 NP_001229395 NM_181504 NP_852556 NM_181523 NP_852664 NM_181524 NP_852665
Function	Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. Plays an important role in signaling in response to FGFR1, FGFR2, FGFR3, FGFR4, KITLG/SCF, KIT, PDGFRA and PDGFRB. Likewise, plays a role in ITGB2 signaling (PubMed:17626883, PubMed:19805105, PubMed:7518429). Modulates the cellular response to ER stress by promoting nuclear translocation of XBP1 isoform 2 in a ER stress- and/or insulin-dependent manner during metabolic overloading in the liver and hence plays a role in glucose tolerance improvement (PubMed:20348923). {ECO:0000269|PubMed:17626883, ECO:0000269|PubMed:19805105, ECO:0000269|PubMed:20348923, ECO:0000269|PubMed:7518429}.
Tissue Specificity	Isoform 2 is expressed in skeletal muscle and brain, and at lower levels in kidney and cardiac muscle. Isoform 2 and isoform 4 are present in skeletal muscle (at protein level). {ECO:0000269|PubMed:8628286}.
Top Pathways	Apoptosis, VEGF signaling pathway, Focal adhesion, Toll-like receptor signaling pathway, Jak-STAT signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

PI3 Kinase p85 Antibody - 4292 from Cell Signaling Technology Prices $246.00 Sizes 100 µl (10 western blots) Host Rabbit Clonality Polyclonal

PI3 Kinase p85α (6G10) Mouse mAb - 13666 from Cell Signaling Technology Prices $246.00 Sizes 100 µl (10 western blots) Host Mouse Clonality Monoclonal Clone 6G10

PI3 Kinase p85 (19H8) Rabbit mAb - 4257 from Cell Signaling Technology Prices $99.00, $246.00 Sizes 20 µl (2 western blots), 100 µl (10 western blots) Host Rabbit Clonality Monoclonal Clone 19H8

PI 3-kinase p85α (D-3) - sc-377482 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

PI 3-kinase p85α (B-9) - sc-1637 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

PI 3-kinase p85α (C-1) - sc-376112 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

PI 3-kinase p85α (N-18) - sc-31969 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

PI 3-kinase p85α (S-20) - sc-31970 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

PI 3-kinase p85α (Z-8) - sc-423 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

PI 3-kinase p85α (2B2.79) - sc-71891 from Santa Cruz Biotechnology Prices $279.00 Sizes 1000 µl supernatant Host Mouse Clonality Monoclonal

PI 3-kinase p85α (3H2838) - sc-71892 from Santa Cruz Biotechnology Prices $279.00 Sizes 1000 µl supernatant Host Mouse Clonality Monoclonal

PI 3-kinase p85α (U13) - sc-56938 from Santa Cruz Biotechnology Prices $279.00 Sizes 1000 µl supernatant Host Mouse Clonality Monoclonal

p-PI 3-kinase p85α (Tyr 508) - sc-12929 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

p-PI 3-kinase p85α (Tyr 467) - sc-293115 from Santa Cruz Biotechnology Prices $279.00 Sizes 100 µg/ml Host Rabbit Clonality Polyclonal

Anti-PI 3 Kinase p85 (SH2) antibody [0.T.112] - ab33093 from Abcam Prices $370.00 Sizes 100 µl Host Mouse Clonality Monoclonal Clone 0.T.112

Anti-PI 3 Kinase p85 alpha + Gamma (phospho Y199 + Y467) antibody - ab196001 from Abcam Prices $370.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-PI 3 Kinase p85 alpha + Gamma antibody - ab74136 from Abcam Prices $380.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-PI 3 Kinase p85 alpha (phospho Y607) antibody - ab192222 from Abcam Prices $370.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-PI 3 Kinase p85 alpha antibody - ab63040 from Abcam Prices $384.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

Anti-PI 3 Kinase p85 alpha antibody - ab71522 from Abcam Prices $359.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-PI 3 Kinase p85 alpha antibody - ab90578 from Abcam Prices $376.00 Sizes 100 µg Host Mouse Clonality Monoclonal

Anti-PI 3 Kinase p85 alpha antibody - ab135952 from Abcam Prices $376.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-PI 3 Kinase p85 alpha antibody - ab65261 from Abcam Prices $359.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-PI 3 Kinase p85 alpha antibody [6G10] - ab135253 from Abcam Prices $384.00 Sizes 100 µl Host Mouse Clonality Monoclonal Clone 6G10

Anti-PI 3 Kinase p85 alpha antibody [Ab6] - ab22653 from Abcam Prices $394.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone Ab6

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