PIK3R1

Gene Symbol	PIK3R1
Entrez Gene	5295
Alt Symbol	AGM7, GRB1, IMD36, p85, p85-ALPHA
Species	Human
Gene Type	protein-coding
Description	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
Other Description	PI3-kinase subunit p85-alpha|PI3K regulatory subunit alpha|phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha|phosphatidylinositol 3-kinase regulatory subunit alpha|phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha)|phosphatidylinositol 3-kinase-associated p-85 alpha|phosphoinositide-3-kinase regulatory subunit|ptdIns-3-kinase regulatory subunit alpha
Swissprots	B3KT19 Q8N1C5 Q4VBZ7 E7EX19 P27986 Q15747 D3DWA0 Q53EM6 Q8IXA2
Accessions	EAW51311 EAW51312 EAW51313 P27986 AF279367 AAO15359 AI124626 AI334281 AK000121 AK094785 BAG52931 AK126345 BAG54309 AK223613 BAD97333 AK294919 BAH11924 AK299743 BAH13115 AW630519 BC030815 AAH30815 BC094795 AAH94795 BE888150 BQ723333 CA427864 CB216668 CT003423 DA487709 HQ447692 ADQ32177 JX133164 AFP86291 JX133165 AFP86292 M61906 U49349 AAB04140 XM_005248542 XP_005248599 XM_011543493 XP_011541795 NM_001242466 NP_001229395 NM_181504 NP_852556 NM_181523 NP_852664 NM_181524 NP_852665
Function	Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. Plays an important role in signaling in response to FGFR1, FGFR2, FGFR3, FGFR4, KITLG/SCF, KIT, PDGFRA and PDGFRB. Likewise, plays a role in ITGB2 signaling (PubMed:17626883, PubMed:19805105, PubMed:7518429). Modulates the cellular response to ER stress by promoting nuclear translocation of XBP1 isoform 2 in a ER stress- and/or insulin-dependent manner during metabolic overloading in the liver and hence plays a role in glucose tolerance improvement (PubMed:20348923). {ECO:0000269|PubMed:17626883, ECO:0000269|PubMed:19805105, ECO:0000269|PubMed:20348923, ECO:0000269|PubMed:7518429}.
Tissue Specificity	Isoform 2 is expressed in skeletal muscle and brain, and at lower levels in kidney and cardiac muscle. Isoform 2 and isoform 4 are present in skeletal muscle (at protein level). {ECO:0000269|PubMed:8628286}.
Top Pathways	Apoptosis, VEGF signaling pathway, Focal adhesion, Toll-like receptor signaling pathway, Jak-STAT signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human PI 3 Kinase p110 alpha + PI 3 kinase p85 alpha full length protein - ab91093 from Abcam Category Protein Prices $302.00, $352.00 Sizes 5 µg, 10 µg Source Baculovirus infected sf9 cells Species Human

Active human PI 3 Kinase p110 alpha + PI 3 kinase p85 alpha full length protein - ab101117 from Abcam Category Protein Prices $302.00, $352.00 Sizes 5 µg, 10 µg Source Baculovirus Species Human

Active human PI 3 Kinase p110 alpha + PI 3 kinase p85 alpha full length protein - ab90730 from Abcam Category Protein Prices $302.00 Sizes 10 µg Source Baculovirus infected sf9 cells Species Human

Active human PI 3 Kinase p110 alpha + PI 3 kinase p85 alpha full length protein - ab196098 from Abcam Category Protein Prices $837.00 Sizes 20 µg Source Baculovirus infected sf9 cells Species Human

Active human PI 3 Kinase p110 delta + PI 3 Kinase p85 alpha full length protein - ab60892 from Abcam Category Protein Prices $492.00 Sizes 20 µg Source Baculovirus infected sf9 cells Species Human

Active human Pik3ca + PIK3R1 full length protein - ab85833 from Abcam Category Protein Prices $302.00, $352.00 Sizes 5 µg, 10 µg Source Baculovirus infected sf9 cells Species Human

Active human PIK3CB + PIK3R1 full length protein - ab85829 from Abcam Category Protein Prices $302.00, $352.00 Sizes 5 µg, 10 µg Source Baculovirus infected sf9 cells Species Human

Active human PIK3CB + PIK3R1 full length protein - ab80378 from Abcam Category Protein Prices $302.00 Sizes 10 µg Source Baculovirus infected sf9 cells Species Human

Human PI 3 Kinase p85 (SH2) full length protein - ab159130 from Abcam Category Protein Source Wheat germ Species Human

Human PI 3 Kinase p85 alpha full length protein - ab84769 from Abcam Category Protein Source Baculovirus infected sf9 cells Species Human

Human PI 3 Kinase p85 alpha peptide - ab71924 from Abcam Category Peptide

Human PI 3 Kinase p85 alpha protein fragment - ab159131 from Abcam Category Protein Source Wheat germ Species Human

Human PI3K p85 full length protein - ab123752 from Abcam Category Protein Source Baculovirus infected sf9 cells Species Human

PIK3R1 / p85 Alpha Antibody Blocking Peptide - LS-E11223 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PIK3R1 / p85 Alpha Antibody Blocking Peptide - LS-E9432 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PI 3-Kinase p85 alpha Partial Recombinant Protein - H00005295-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

PI 3-Kinase p85 alpha Recombinant Protein - H00005295-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

PI 3-Kinase p85 alpha Protein - NBP1-99881 from Novus Biologicals Category Protein Prices $309.00 Sizes 5 µg

PI 3-Kinase p85 alpha Peptide - P3001 from Novus Biologicals Category Peptide Species Human

PI 3-Kinase p85 alpha Peptide - P3000 from Novus Biologicals Category Peptide Species Human

PI 3-Kinase p85 alpha Peptide - P2999 from Novus Biologicals Category Peptide Species Human

PI 3-Kinase p85 alpha Peptide - P2998 from Novus Biologicals Category Peptide Species Human

PIK3R1-Antibody-Y580-Blocking-Peptide - BP8023f from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

PIK3R1-Antibody-Y556-Blocking-Peptide - BP8023e from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

PIK3R1-Antibody-Y528-Blocking-Peptide - BP8023c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

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