| Gene Symbol |
PIK3R1
|
| Entrez Gene |
5295
|
| Alt Symbol |
AGM7, GRB1, IMD36, p85, p85-ALPHA
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
|
| Other Description |
PI3-kinase subunit p85-alpha|PI3K regulatory subunit alpha|phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha|phosphatidylinositol 3-kinase regulatory subunit alpha|phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha)|phosphatidylinositol 3-kinase-associated p-85 alpha|phosphoinositide-3-kinase regulatory subunit|ptdIns-3-kinase regulatory subunit alpha
|
| Swissprots |
B3KT19 Q8N1C5 Q4VBZ7 E7EX19 P27986 Q15747 D3DWA0 Q53EM6 Q8IXA2
|
| Accessions |
EAW51311 EAW51312 EAW51313 P27986 AF279367 AAO15359 AI124626 AI334281 AK000121 AK094785 BAG52931 AK126345 BAG54309 AK223613 BAD97333 AK294919 BAH11924 AK299743 BAH13115 AW630519 BC030815 AAH30815 BC094795 AAH94795 BE888150 BQ723333 CA427864 CB216668 CT003423 DA487709 HQ447692 ADQ32177 JX133164 AFP86291 JX133165 AFP86292 M61906 U49349 AAB04140 XM_005248542 XP_005248599 XM_011543493 XP_011541795 NM_001242466 NP_001229395 NM_181504 NP_852556 NM_181523 NP_852664 NM_181524 NP_852665
|
| Function |
Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. Plays an important role in signaling in response to FGFR1, FGFR2, FGFR3, FGFR4, KITLG/SCF, KIT, PDGFRA and PDGFRB. Likewise, plays a role in ITGB2 signaling (PubMed:17626883, PubMed:19805105, PubMed:7518429). Modulates the cellular response to ER stress by promoting nuclear translocation of XBP1 isoform 2 in a ER stress- and/or insulin-dependent manner during metabolic overloading in the liver and hence plays a role in glucose tolerance improvement (PubMed:20348923). {ECO:0000269|PubMed:17626883, ECO:0000269|PubMed:19805105, ECO:0000269|PubMed:20348923, ECO:0000269|PubMed:7518429}.
|
| Tissue Specificity |
Isoform 2 is expressed in skeletal muscle and brain, and at lower levels in kidney and cardiac muscle. Isoform 2 and isoform 4 are present in skeletal muscle (at protein level). {ECO:0000269|PubMed:8628286}.
|
| Top Pathways |
Apoptosis, VEGF signaling pathway, Focal adhesion, Toll-like receptor signaling pathway, Jak-STAT signaling pathway
|