PIK3R1

Gene Symbol PIK3R1
Entrez Gene 5295
Alt Symbol AGM7, GRB1, IMD36, p85, p85-ALPHA
Species Human
Gene Type protein-coding
Description phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
Other Description PI3-kinase subunit p85-alpha|PI3K regulatory subunit alpha|phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha|phosphatidylinositol 3-kinase regulatory subunit alpha|phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha)|phosphatidylinositol 3-kinase-associated p-85 alpha|phosphoinositide-3-kinase regulatory subunit|ptdIns-3-kinase regulatory subunit alpha
Swissprots B3KT19 Q8N1C5 Q4VBZ7 E7EX19 P27986 Q15747 D3DWA0 Q53EM6 Q8IXA2
Accessions EAW51311 EAW51312 EAW51313 P27986 AF279367 AAO15359 AI124626 AI334281 AK000121 AK094785 BAG52931 AK126345 BAG54309 AK223613 BAD97333 AK294919 BAH11924 AK299743 BAH13115 AW630519 BC030815 AAH30815 BC094795 AAH94795 BE888150 BQ723333 CA427864 CB216668 CT003423 DA487709 HQ447692 ADQ32177 JX133164 AFP86291 JX133165 AFP86292 M61906 U49349 AAB04140 XM_005248542 XP_005248599 XM_011543493 XP_011541795 NM_001242466 NP_001229395 NM_181504 NP_852556 NM_181523 NP_852664 NM_181524 NP_852665
Function Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. Plays an important role in signaling in response to FGFR1, FGFR2, FGFR3, FGFR4, KITLG/SCF, KIT, PDGFRA and PDGFRB. Likewise, plays a role in ITGB2 signaling (PubMed:17626883, PubMed:19805105, PubMed:7518429). Modulates the cellular response to ER stress by promoting nuclear translocation of XBP1 isoform 2 in a ER stress- and/or insulin-dependent manner during metabolic overloading in the liver and hence plays a role in glucose tolerance improvement (PubMed:20348923). {ECO:0000269|PubMed:17626883, ECO:0000269|PubMed:19805105, ECO:0000269|PubMed:20348923, ECO:0000269|PubMed:7518429}.
Tissue Specificity Isoform 2 is expressed in skeletal muscle and brain, and at lower levels in kidney and cardiac muscle. Isoform 2 and isoform 4 are present in skeletal muscle (at protein level). {ECO:0000269|PubMed:8628286}.
Top Pathways Apoptosis, VEGF signaling pathway, Focal adhesion, Toll-like receptor signaling pathway, Jak-STAT signaling pathway

Mouse/Human/Rat Phospho-PIK3R1 / p85 Alpha (Tyr467/199) ELISA Kit (Cell-Based Phosphorylation ELISA) - LS-F1437 from LifeSpan Bioscience

Category ELISA Kit
Prices $550.00
Sizes 1 plate

Mouse/Human/Rat PIK3R1/PIK3R3 ELISA Kit (Cell-Based ELISA) - LS-F2241 from LifeSpan Bioscience

Category ELISA Kit
Prices $450.00
Sizes 1 plate

PIK3R1 (Human) IP-WB Antibody Pair - H00005295-PW1 from Acris Antibodies

Category Antibody Pair
Prices $610.00
Sizes 1 set

Phosphotylinosital 3 kinase, ELISA Kit - MBS732497 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Phosphotylinosital 3 kinase, ELISA Kit - MBS750770 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Phosphotylinosital 3 kinase, ELISA Kit - MBS752309 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
Sensitivity 0.1ng/mL.

Phosphotylinosital 3 kinase, ELISA Kit - MBS728258 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
Sensitivity 1.0 pg/mL.

Phosphotylinosital 3 kinase, ELISA Kit - MBS750275 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Phosphotylinosital 3 kinase, ELISA Kit - MBS745158 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
Sensitivity 0.1 ng/mL.

Phosphotylinosital 3 kinase, ELISA Kit - MBS749526 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00
Sizes 48 strip wells, 96 strip wells

Phosphotylinosital 3 kinase, ELISA Kit - MBS720875 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Phosphotylinosital 3 kinase, ELISA Kit - MBS752122 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

PI3-kinase p85-alpha/gamma Colorimetric Cell-Based ELISA Kit - CB5553 from Assay Biotechnology

Category ELISA Kit
Prices $380.00, $760.00, $1,140.00
Sizes 1 kit, 2 kits, 3 kits
Range > 5000 Cells

PI3-kinase p85-alpha/gamma (Phospho-Tyr467/199) Colorimetric Cell-Based ELISA Kit - CBP1475 from Assay Biotechnology

Category ELISA Kit
Prices $480.00, $960.00, $1,440.00
Sizes 1 kit, 2 kits, 3 kits
Range > 5000 Cells

phosphoinositide-3-kinase, regulatory subunit 1 (alpha) , ELISA Kit - MBS9338226 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Phosphotylinosital 3 kinase, ELISA Kit - MBS726795 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
Sensitivity 0.1 ng/mL.

Phosphotylinosital 3 kinase, ELISA Kit - MBS727070 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Human PIK3R1 ELISA Kit - E029128 from Biobool

Category ELISA Kit
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