Fzd1
| Gene Symbol | Fzd1 |
|---|---|
| Entrez Gene | 14362 |
| Alt Symbol | AW227548, FZ-1, Fz1 |
| Species | Mouse |
| Gene Type | protein-coding |
| Description | frizzled homolog 1 (Drosophila) |
| Other Description | frizzled-1|mFz1 |
| Swissprots | O08974 Q7TS82 O70421 |
| Accessions | EDL14633 O70421 AF005202 AAC01952 AF054623 AAC12873 AK143101 BAE25269 BC053010 AAH53010 BE948559 NM_021457 NP_067432 |
| Function | Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK- 3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. |
| Subcellular Location | Membrane; Multi-pass membrane protein. Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. |
| Tissue Specificity | Expressed in chondrocytes. |
| Top Pathways | Wnt signaling pathway, Basal cell carcinoma, Melanogenesis, HTLV-I infection, Hippo signaling pathway |
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