Fzd1

Gene Symbol	Fzd1
Entrez Gene	14362
Alt Symbol	AW227548, FZ-1, Fz1
Species	Mouse
Gene Type	protein-coding
Description	frizzled homolog 1 (Drosophila)
Other Description	frizzled-1|mFz1
Swissprots	O08974 Q7TS82 O70421
Accessions	EDL14633 O70421 AF005202 AAC01952 AF054623 AAC12873 AK143101 BAE25269 BC053010 AAH53010 BE948559 NM_021457 NP_067432
Function	Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK- 3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.
Subcellular Location	Membrane; Multi-pass membrane protein. Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Tissue Specificity	Expressed in chondrocytes.
Top Pathways	Wnt signaling pathway, Basal cell carcinoma, Melanogenesis, HTLV-I infection, Hippo signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Recombinant Mouse Frizzled-1 Fc Chimera, CF - 1120-FZ-050 from R&D Systems Category Protein Source Mouse myeloma cell line, NS0-derived

Mouse Frizzled-1 protein - orb83375 from Biorbyt Category Protein Prices $400.00, $612.00 Sizes 50 μg, 100 μg Source Human Species Mouse

Recombinant Mouse Fzd1, His tagged - Fzd1-2292M from Creative Biomart Category Protein Source Human Cells Species Mouse

Recombinant Mouse Fzd1, Fc Chimera - Fzd1-1014M from Creative Biomart Category Protein Source NSO Cells Species Mouse

FZD1 - PN201585 from Elabscience Category Protein Prices $225.00, $475.00 Sizes 10 μg, 50 μg Source Human Cells Species Mouse

Mouse Frizzled-1 / FZD1 Protein (His Tag) - 50092-M08H-50 from Sino Biological Category Protein Prices $178.00, $178.00 Sizes 50 µg, 100 µg Source Human Cells Species Mouse

Recombinant Mouse Frizzled-1 Fc Chimera Protein, CF - 1120-FZ from R&D Systems Category Protein Prices $329.00 Sizes 50 µg Source Mouse myeloma cell line, NS0-derived Mouse Frizzled-1 (Gln72 - His248) with substitution Met122Ile Accession # O70421 IEGRMD Human IgG1 (Pro100 - Lys330) N-terminus C-terminus Species Mouse

Recombinant Mouse Frizzled-1 / FZD1 Protein (His tag) - PKSM040870 from Elabscience Category Protein Source Human Cell Species Mouse

Mouse Frizzled 1 protein - orb334378 from Biorbyt Category Protein Prices $230.00, $349.00, $1,675.00, $2,372.00 Sizes 10 μg, 50 μg, 500 μg, 1 mg Species Mouse

Frizzled-1 (Fzd1), Recombinant Protein - MBS1098409 from MyBioSource Category Protein Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Mouse

Frizzled-1 (Fzd1), Recombinant Protein - MBS7015389 from MyBioSource Category Protein Prices $1,370.00, $2,355.00, $3,560.00 Sizes 10 µg, 50 µg, 100 µg Source Cell Free Expression Species Mouse

FZD1 Recombinant Protein (OPCD03356) - OPCD03356 from Aviva Systems Biology Category Protein Source E.coli Species Mouse

Mouse Frizzled-1 / FZD1 Protein (His Tag) - 50092-M08H from ABclonal Category Protein Prices $178.00, $298.00 Sizes 50 µg, 100 µg Source Human Cells Species Mouse

Frizzled-1 Recombinant Protein - 92-653 from ProSci Category Protein Prices $275.00 Sizes 50 µg Source Human Cells Species Mouse

Frizzled-1 / FZD1, Recombinant Protein - MBS2547167 from MyBioSource Category Protein Prices $475.00, $775.00 Sizes 50 µg, 100 µg Source Human Cells

Recombinant Mouse Frizzled 1,FZD1 (C-Fc) - AP76264 from Signalway Antibody Category Protein Prices $239.00, $389.00, $1,899.00, $2,649.00 Sizes 10 µg, 50 µg, 500 µg, 1 mg Source Human Cells Species Mouse

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