| Gene Symbol |
Gja1
|
| Entrez Gene |
24392
|
| Alt Symbol |
Cx43
|
| Species |
Rat
|
| Gene Type |
protein-coding
|
| Description |
gap junction protein, alpha 1
|
| Other Description |
connexin 43|connexin-43|gap junction 43 kDa heart protein|gap junction alpha-1 protein|gap junction membrane channel protein alpha 1
|
| Swissprots |
P08050 Q53ZE1
|
| Accessions |
EDL92907 EDL92908 EDL92909 EDL92910 P08050 AY324140 AAP88589 AY555736 AAS68153 AY555737 AAS68154 AY555738 AAS68155 AY555739 AAS68156 AY555740 AAS68157 BC081842 AAH81842 XM_006256503 XP_006256565 NM_012567 NP_036699
|
| Function |
Gap junction protein that acts as a regulator of bladder capacity. A gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. Negative regulator of bladder functional capacity: acts by enhancing intercellular electrical and chemical transmission, thus sensitizing bladder muscles to cholinergic neural stimuli and causing them to contract (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cell membrane {ECO:0000269|PubMed:18636092}; Multi-pass membrane protein {ECO:0000269|PubMed:18636092}. Cell junction, gap junction {ECO:0000269|PubMed:18636092}.
|
| Top Pathways |
Gap junction, Arrhythmogenic right ventricular cardiomyopathy (ARVC)
|