FASLG

Gene Symbol FASLG
Entrez Gene 356
Alt Symbol ALPS1B, APT1LG1, APTL, CD178, CD95-L, CD95L, FASL, TNFSF6
Species Human
Gene Type protein-coding
Description Fas ligand (TNF superfamily, member 6)
Other Description CD95 ligand|apoptosis (APO-1) antigen ligand 1|apoptosis antigen ligand|fas antigen ligand|tumor necrosis factor ligand superfamily member 6
Swissprots Q9BZP9 P48023
Accessions AAB96632 AAC39768 ABK41922 BAA32542 CAX86839 CBX53895 CCA94585 EAW90935 EAW90936 P48023 AF288573 AAG60017 AK314874 BAG37389 AY225406 AAO43991 AY858799 AAX49569 BC017502 AAH17502 D38122 BAA07320 DA916336 DQ893466 ABM84392 DQ896147 ABM87146 U08137 AAC50071 U11821 AAC50124 X89102 CAA61474 NM_000639 NP_000630 NM_001302746 NP_001289675
Function Cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells. May be involved in cytotoxic T-cell mediated apoptosis and in T-cell development. TNFRSF6/FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. Binding to the decoy receptor TNFRSF6B/DcR3 modulates its effects. {ECO:0000269|PubMed:17557115}.
Subcellular Location FasL intracellular domain: Nucleus. Note=The FasL ICD cytoplasmic form is translocated into the nucleus.
Top Pathways PI3K-Akt signaling pathway, Herpes simplex infection, Chagas disease (American trypanosomiasis), Non-alcoholic fatty liver disease (NAFLD), Proteoglycans in cancer

FasL Antibody - 4273 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of recombinant human FasL (amino acids 134-281, 5 ng) and extracts from SW620 and COLO201 cell lines, using FasL Antibody.

FAS-L (2.1) - sc-33716 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Western blot analysis of FAS-L expression in HL-60 whole cell lysate immunoprecipitated with FAS-L (2.1): sc-33716 and detected with FAS-L (N-20): sc-834.

FAS-L (4H9) - sc-18897 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Hamster
Clonality Monoclonal
FAS-L (4H9): sc-18897. Western blot analysis of FAS-L expression in K-562 (A) and HL-60 (B) whole cell lysates immunoprecipitated with FAS-L (4H9): sc-18897 and detected with FAS-L (C-178): sc-6237.

FAS-L (C-178) - sc-6237 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
FAS-L (C-178): sc-6237. Western blot analysis of FAS-L expression in K-562 (A), AML-193 (B) and HL-60 (C) whole cell lysates.

FAS-L (C-20) - sc-957 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
FAS-L (C-20): sc-957. Immunoperoxidase staining of formalin fixed, paraffin-embedded human kidney tissue showing cytoplasmic and nuclear staining of cells in glomeruli and cells in tubules.

FAS-L (N-20) - sc-834 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
FAS-L (N-20): sc-834-G. Immunoperoxidase staining of formalin fixed, paraffin-embedded human nasopharynx tissue showing cytoplasmic and nuclear staining of respiratory epithelial cells.

FAS-L (NOK-1) - sc-19681 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
FAS-L (NOK-1): sc-19681. Western blot analysis of FAS-L expression in K-562 (A) and HL-60 (B) whole cell lysates immunoprecipitated with FAS-L (NOK-1): sc-19681 and detected with FAS-L (N-20): sc-834.

FAS-L (Q-20) - sc-956 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
FAS-L (Q-20): sc-956. FAS-L expression in MS plaque. Confocal microscopy showing cells labeled by TUNEL (yellow) and sc-956 (red). Arrows indicate double-labeled cells. Reproduced from P. Dowling et al.,The Journal of Experimental Medicine, 1996, vol: 184, 1513-1518 by copyright permission of the Rockefeller University Press.

FAS-L (1.BB.37) - sc-71096 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Hamster
Clonality Monoclonal

Anti-Fas Ligand antibody - ab15285 from Abcam

Prices $400.00
Sizes 500 µl
Host Rabbit
Clonality Polyclonal
ab15285 at 1/100 dilution staining Fas Ligand in human prostate tissue section by Immunohistochemistry (Formalin/ PFA fixed paraffin embedded tissue sections).

Anti-Fas Ligand antibody - ab68338 from Abcam

Prices $390.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-Fas Ligand antibody (ab68338) at 1 µg/ml + HeLa cell lysate

Anti-Fas Ligand antibody - ab2440 from Abcam

Host Rabbit
Clonality Polyclonal

Anti-Fas Ligand antibody - ab21233 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Formalin fixed paraffin embedded human prostate stained with Fas Ligand using ABC and AEC chromogen.

Anti-Fas Ligand antibody - ab134401 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
IHC image of Fas Ligand staining in Human normal prostate formalin fixed paraffin embedded tissue section, performed on a Leica Bond™ system using the standard protocol F. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH6, epitope retrieval solution 1) for 20 mins. The section was then incubated with ab134401, 1µg/ml, for 15 mins at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. For other IHC staining systems (automated and non-automated) customers should optimize variable parameters such as antigen retrieval conditions, primary antibody concentration and antibody incubation times.

Anti-Fas Ligand antibody - ab186671 from Abcam

Host Goat
Clonality Polyclonal
Immunohistochemical analysis of formalin-fixed paraffin-embedded Human angiosarcoma tissue, labeling Fas Ligand with ab186671 at 2.5 µg/ml. An HRP-labeled polymer detection system was used with a AB chromogen.

Anti-Fas Ligand antibody - ab10041 from Abcam

Prices $378.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-Fas Ligand antibody - ab53067 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Fas Ligand antibody (ab53067) at 1/500 dilutionLane 1 : 293 cell extractLane 2 : 293 cell extract with immunising peptide

Anti-Fas Ligand antibody - ab53282 from Abcam

Prices $376.00
Sizes 50 µg
Host Chicken
Clonality Polyclonal
Anti-Fas Ligand antibody (ab53282) at 1/2000 dilution + E coli-derived fusion proteinSecondaryGoat anti-IgY-HRP at 1/1000 dilution

Anti-Fas Ligand antibody [Alf1.2] - ab10511 from Abcam

Prices $372.00
Sizes 50 µl
Host Mouse
Clonality Monoclonal
Clone Alf1.2

Anti-Fas Ligand antibody [Alf2.1] - ab10509 from Abcam

Prices $370.00
Sizes 50 µl
Host Mouse
Clonality Monoclonal
Clone Alf2.1

Anti-Fas Ligand antibody [B-R17] - ab47175 from Abcam

Prices $378.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone B-R17
FACS analysis of Fas Ligand expressin cells in FasL transfected 293T cell line using ab47175.

Anti-Fas Ligand antibody [B-R17] - ab47174 from Abcam

Prices $376.00
Sizes 1 ml
Host Mouse
Clonality Monoclonal
Clone B-R17
FACS analysis of Fas Ligand expression in Fas L transfected 293T cell line using ab47174.

Anti-Fas Ligand antibody [B-R17] (Biotin) - ab27409 from Abcam

Prices $378.00
Sizes 1 ml
Host Mouse
Clonality Monoclonal
Clone B-R17
Ab27409, staining Fas Ligand by FACS.

Anti-Fas Ligand antibody (Biotin) - ab186672 from Abcam

Host Goat
Clonality Polyclonal

Anti-Fas Ligand antibody (Biotin) - ab17881 from Abcam

Host Goat
Clonality Polyclonal
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