Smad7

Gene Symbol	Smad7
Entrez Gene	17131
Alt Symbol	Madh7
Species	Mouse
Gene Type	protein-coding
Description	SMAD family member 7
Other Description	MAD homolog 7|MAD homolog 8|SMAD 7|madh8|mothers against DPP homolog 7|mothers against DPP homolog 8|mothers against decapentaplegic homolog 7|mothers against decapentaplegic homolog 8
Swissprots	O88709 O35253
Accessions	EDL09492 EDL09493 O35253 AB221688 AF015260 AAB81353 AJ000550 CAA04182 AJ000551 CAA04183 AK013237 AK133505 BC137638 AAI37639 XM_006525703 XP_006525766 NM_008543 NM_001042660 NP_001036125
Function	Antagonist of signaling by TGF-beta (transforming growth factor) type 1 receptor superfamily members; has been shown to inhibit TGF-beta (Transforming growth factor) and activin signaling by associating with their receptors thus preventing SMAD2 access. Functions as an adapter to recruit SMURF2 to the TGF-beta receptor complex. Also acts by recruiting the PPP1R15A- PP1 complex to TGFBR1, which promotes its dephosphorylation. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator (By similarity). {ECO:0000250}.
Subcellular Location	Nucleus. Cytoplasm. Note=Interaction with NEDD4L or RNF111 induces translocation from the nucleus to the cytoplasm. TGF-beta stimulates its translocation from the nucleus to the cytoplasm. PDPK1 inhibits its translocation from the nucleus to the cytoplasm in response to TGF-beta (By similarity). {ECO:0000250}.
Tissue Specificity	Ubiquitous in various organs, with higher levels in brain and kidney.
Top Pathways	TGF-beta signaling pathway, Endocytosis, Hippo signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones

Mothers Against Decapentaplegic Homolog 7, Mouse, ELISA Kit - E03S0270 from ARP American Research Products Category ELISA Kit Prices $535.00, $735.00 Sizes 48 t, 96 t Sensitivity 0.1ng/ml Range 0.5-10ng/mL,

Mothers against decapentaplegic homolog 7, Smad7, Mouse, ELISA Kit - E0648m from ARP American Research Products Category ELISA Kit Prices $596.00 Sizes 96 t Range 0.312-20 ng/mL

Mouse Smad7 ELISA Kit - MS0277 from NeoScientific Category ELISA Kit Prices $495.00 Sizes 96 t

Mothers Against Decapentaplegic Homolog 7 (Smad7), ELISA Kit - MBS2021504 from MyBioSource Category ELISA Kit Prices $345.00, $515.00, $695.00, $2,840.00, $5,180.00 Sizes 24 -strip-wells, 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity Typically less than 0.055ng/mL. Range 0.156-10ng/mL

Mothers Against Decapentaplegic Homolog 7 (Smad7), ELISA Kit - MBS2020338 from MyBioSource Category ELISA Kit Prices $370.00, $550.00, $750.00, $3,065.00, $5,550.00 Sizes 24 -strip-wells, 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity Typically less than 0.054ng/mL. Range 0.156-10ng/mL

Mouse Smad7/MADH7(Mothers Against Decapentaplegic Homolog 7) ELISA Kit - E-EL-M1066 from Elabscience Category ELISA Kit Sensitivity 0.19 ng/mL Range 0.31—20 ng/mL

Mouse Mothers Against Decapentaplegic Homolog 7 ELISA - E03S0270 from BlueGene Biotech Category ELISA Kit

Mouse Smad7/MADH7(Mothers Against Decapentaplegic Homolog 7) ELISA Kit - E-EL-M1066 from Iwai North America Inc. Category ELISA Kit Prices $580.00 Sizes 1 kit Sensitivity 0.19 ng/mL Range 0.31~20 ng/mL

Mouse Mothers against decapentaplegic homolog 7 ELISA Kit - abx254783 from Abbexa Category ELISA Kit Range 0.312 ng/ml - 20 ng/ml

Smad7/MADH7 (Mothers Against Decapentaplegic Homolog 7), CLIA Kit - MBS2531583 from MyBioSource Category CLIA Kit Prices $450.00, $535.00, $2,255.00, $3,975.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 18.75pg/mL Range 31.25-2000pg/mL

Mouse Smad7 ELISA Kit - orb365345 from Biorbyt Category ELISA Kit Prices $519.00, $587.00 Sizes 48 test, 96 test Range Detection Range: 0.313-20 ng/mL Detection low threshold: 0.07 ng/mL

Mouse Smad7 ELISA Kit - abx572054 from Abbexa Category ELISA Kit Sensitivity 0.07 ng/ml Range 0.313 ng/ml - 20 ng/ml

Mouse Mothers against decapentaplegic homolog 7 ELISA Kit - EKE53063 from Biomatik Category ELISA Kit Prices $685.00, $2,913.00, $5,483.00 Sizes 96 t, 5x96t, 10x96t Range 0.312-20 ng/mL

Smad7 - EKM0856 from Nordic BioSite Sensitivity 0.188ng/ml Range 0.312-20ng/ml

Smad7 - EKM856 from Nordic BioSite Sensitivity 0.188ng/ml Range 0.312-20ng/ml

Mouse Smad7 ELISA Kit - E060475 from Biobool Category ELISA Kit Sensitivity <0.188ng/ml

SMAD7 ELISA Kit (Mouse) (OKEH03172) - OKEH03172 from Aviva Systems Biology Category ELISA Kit Prices $425.00 Sizes 96 wells Sensitivity 0.156 ng/mL Range 0.312 - 20 ng/mL

Mouse Smad7 ELISA Kit - EMS0277 from ABclonal Category ELISA Kit Prices $495.00 Sizes 96 t

Human Mothers against decapentaplegic homolog 7 ELISA Kit - EK2081 from Signalway Antibody Category ELISA Kit Prices $599.00 Sizes 1x96t Sensitivity less than 0.1ng/mL Range 0.156-10 ng/mL

Mothers against decapentaplegic homolog 7, ELISA Kit - MBS9425928 from MyBioSource Category ELISA Kit Prices $555.00 Sizes 96 tests Sensitivity Less than 0.1ng/mL Range 0.156-10 ng/mL

Mothers Against Decapentaplegic Homolog 7, ELISA Kit - MBS765524 from MyBioSource Category ELISA Kit Prices $295.00, $390.00, $1,615.00, $3,015.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.094ng/ml Range 0.156-10ng/ml

Mothers against decapentaplegic homolog 7, ELISA Kit - MBS285587 from MyBioSource Category ELISA Kit Prices $425.00, $720.00, $3,160.00, $6,055.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Mothers against decapentaplegic homolog 7, ELISA Kit - MBS763280 from MyBioSource Category ELISA Kit Prices $295.00, $390.00, $1,615.00, $3,015.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.188ng/ml Range 0.312-20ng/ml

Mothers against decapentaplegic homolog 7, ELISA Kit - MBS2885267 from MyBioSource Category ELISA Kit Prices $380.00, $500.00, $2,170.00, $3,840.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Range 0.312-20 ng/mL

Mothers Against Decapentaplegic Homolog 7 (Smad7), ELISA Kit - MBS456222 from MyBioSource Category ELISA Kit Prices $395.00, $520.00, $2,275.00, $4,420.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.07ng/mL Range 0.312-20ng/mL

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