Smad7

Gene Symbol Smad7
Entrez Gene 17131
Alt Symbol Madh7
Species Mouse
Gene Type protein-coding
Description SMAD family member 7
Other Description MAD homolog 7|MAD homolog 8|SMAD 7|madh8|mothers against DPP homolog 7|mothers against DPP homolog 8|mothers against decapentaplegic homolog 7|mothers against decapentaplegic homolog 8
Swissprots O88709 O35253
Accessions EDL09492 EDL09493 O35253 AB221688 AF015260 AAB81353 AJ000550 CAA04182 AJ000551 CAA04183 AK013237 AK133505 BC137638 AAI37639 XM_006525703 XP_006525766 NM_008543 NM_001042660 NP_001036125
Function Antagonist of signaling by TGF-beta (transforming growth factor) type 1 receptor superfamily members; has been shown to inhibit TGF-beta (Transforming growth factor) and activin signaling by associating with their receptors thus preventing SMAD2 access. Functions as an adapter to recruit SMURF2 to the TGF-beta receptor complex. Also acts by recruiting the PPP1R15A- PP1 complex to TGFBR1, which promotes its dephosphorylation. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator (By similarity). {ECO:0000250}.
Subcellular Location Nucleus. Cytoplasm. Note=Interaction with NEDD4L or RNF111 induces translocation from the nucleus to the cytoplasm. TGF-beta stimulates its translocation from the nucleus to the cytoplasm. PDPK1 inhibits its translocation from the nucleus to the cytoplasm in response to TGF-beta (By similarity). {ECO:0000250}.
Tissue Specificity Ubiquitous in various organs, with higher levels in brain and kidney.
Top Pathways TGF-beta signaling pathway, Endocytosis, Hippo signaling pathway

Smad7 CRISPR/Cas9 KO Plasmid (m) - sc-421530 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

Smad7 HDR Plasmid (m) - sc-421530-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

Smad7 Double Nickase Plasmid (m) - sc-421530-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

Smad7 Double Nickase Plasmid (m2) - sc-421530-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

Smad7 CRISPR Activation Plasmid (m) - sc-421530-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

Smad7 CRISPR Activation Plasmid (m2) - sc-421530-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

Smad7 Lentiviral Activation Particles (m) - sc-421530-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

Smad7 Lentiviral Activation Particles (m2) - sc-421530-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

Smad7 siRNA (m) - sc-36509 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Mouse

Smad7 shRNA Plasmid (m) - sc-36509-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Mouse

Smad7 shRNA (m) Lentiviral Particles - sc-36509-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Mouse

CompoZr® Knockout ZFN Kit - CKOZFN41645 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND41645 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

SMAD7 siRNA (Mouse) - CRM2439 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Mouse

SMAD7 - MBS8207733 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Mouse

shRNA set against Mouse SMAD7 (NM_001042660.1) - SHH413024 from Creative biogene

Category siRNA
Species Reactivities Mouse

shRNA set against Mouse Smad7(NM_001042660.1) - SHL015274 from Creative biogene

Category siRNA
Species Reactivities Mouse

Mouse SMAD7 siRNA - orb281915 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Mouse

SMAD7 shRNA Plasmid (Mouse) - CHM2439 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Mouse

SMAD7 miRNA 3'UTR clone - MiUTR1M-10976 from Creative biogene

Species Reactivities Mouse
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