| Gene Symbol |
Smad7
|
| Entrez Gene |
17131
|
| Alt Symbol |
Madh7
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
SMAD family member 7
|
| Other Description |
MAD homolog 7|MAD homolog 8|SMAD 7|madh8|mothers against DPP homolog 7|mothers against DPP homolog 8|mothers against decapentaplegic homolog 7|mothers against decapentaplegic homolog 8
|
| Swissprots |
O88709 O35253
|
| Accessions |
EDL09492 EDL09493 O35253 AB221688 AF015260 AAB81353 AJ000550 CAA04182 AJ000551 CAA04183 AK013237 AK133505 BC137638 AAI37639 XM_006525703 XP_006525766 NM_008543 NM_001042660 NP_001036125
|
| Function |
Antagonist of signaling by TGF-beta (transforming growth factor) type 1 receptor superfamily members; has been shown to inhibit TGF-beta (Transforming growth factor) and activin signaling by associating with their receptors thus preventing SMAD2 access. Functions as an adapter to recruit SMURF2 to the TGF-beta receptor complex. Also acts by recruiting the PPP1R15A- PP1 complex to TGFBR1, which promotes its dephosphorylation. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Nucleus. Cytoplasm. Note=Interaction with NEDD4L or RNF111 induces translocation from the nucleus to the cytoplasm. TGF-beta stimulates its translocation from the nucleus to the cytoplasm. PDPK1 inhibits its translocation from the nucleus to the cytoplasm in response to TGF-beta (By similarity). {ECO:0000250}.
|
| Tissue Specificity |
Ubiquitous in various organs, with higher levels in brain and kidney.
|
| Top Pathways |
TGF-beta signaling pathway, Endocytosis, Hippo signaling pathway
|