Smad7

Gene Symbol Smad7
Entrez Gene 17131
Alt Symbol Madh7
Species Mouse
Gene Type protein-coding
Description SMAD family member 7
Other Description MAD homolog 7|MAD homolog 8|SMAD 7|madh8|mothers against DPP homolog 7|mothers against DPP homolog 8|mothers against decapentaplegic homolog 7|mothers against decapentaplegic homolog 8
Swissprots O88709 O35253
Accessions EDL09492 EDL09493 O35253 AB221688 AF015260 AAB81353 AJ000550 CAA04182 AJ000551 CAA04183 AK013237 AK133505 BC137638 AAI37639 XM_006525703 XP_006525766 NM_008543 NM_001042660 NP_001036125
Function Antagonist of signaling by TGF-beta (transforming growth factor) type 1 receptor superfamily members; has been shown to inhibit TGF-beta (Transforming growth factor) and activin signaling by associating with their receptors thus preventing SMAD2 access. Functions as an adapter to recruit SMURF2 to the TGF-beta receptor complex. Also acts by recruiting the PPP1R15A- PP1 complex to TGFBR1, which promotes its dephosphorylation. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator (By similarity). {ECO:0000250}.
Subcellular Location Nucleus. Cytoplasm. Note=Interaction with NEDD4L or RNF111 induces translocation from the nucleus to the cytoplasm. TGF-beta stimulates its translocation from the nucleus to the cytoplasm. PDPK1 inhibits its translocation from the nucleus to the cytoplasm in response to TGF-beta (By similarity). {ECO:0000250}.
Tissue Specificity Ubiquitous in various organs, with higher levels in brain and kidney.
Top Pathways TGF-beta signaling pathway, Endocytosis, Hippo signaling pathway

Recombinant Mothers Against Decapentaplegic Homolog 7 (Smad7) - RPA648Mu01 from Cloud-clone

Category Protein
Source E.coli
Species Mouse

Recombinant Mouse Mothers against decapentaplegic homolog 7(Smad7) - CSB-YP021793MO CSB-EP021793MO CSB-BP021793MO CSB-MP021793MO from Cusabio

Category Protein
Source Yeast or E.coli or Baculovirus or Mammalian cell
Species Mouse

Mothers against decapentaplegic homolog 7 (Smad7), Recombinant Protein - MBS1140782 from MyBioSource

Category Protein
Prices $1,200.00, $1,200.00, $1,420.00, $1,420.00, $1,940.00, $1,940.00, $2,405.00, $2,405.00
Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell)
Source E Coli or Yeast or Baculovirus or Mammalian Cell
Species Mouse
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