EIF2S1

Gene Symbol	EIF2S1
Entrez Gene	1965
Alt Symbol	EIF-2, EIF-2A, EIF-2alpha, EIF2, EIF2A
Species	Human
Gene Type	protein-coding
Description	eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa
Other Description	eIF-2-alpha|eukaryotic translation initiation factor 2 subunit 1|eukaryotic translation initiation factor 2 subunit alpha
Swissprots	P05198
Accessions	EAW80933 EAW80934 P05198 AK297244 BAG59724 AK312442 BAG35351 BC002513 AAH02513 BX161521 CAD61953 D28379 BAA05745 DQ892151 ABM83077 DQ895347 ABM86273 J02645 AAA52373 U26032 NM_004094 NP_004085
Function	Functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S preinitiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must exchange with GTP by way of a reaction catalyzed by eIF-2B.
Subcellular Location	Cytoplasmic granule {ECO:0000250}. Note=The cytoplasmic granules are stress granules which are a dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress. Colocalizes with NANOS3 in the stress granules (By similarity). {ECO:0000250}.
Top Pathways	Protein processing in endoplasmic reticulum, RNA transport, Hepatitis C, Measles, Influenza A

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

PathScan ® Phospho-eIF2α (Ser51) Sandwich ELISA Kit - 7286 from Cell Signaling Technology Category ELISA Kit Prices $489.00 Sizes 1 kit (96 assays)

PathScan ® Total eIF2α Sandwich ELISA Kit - 7952 from Cell Signaling Technology Category ELISA Kit Prices $489.00 Sizes 1 kit (96 assays)

PathScan ® Phospho-eIF2α (Ser51) Sandwich ELISA Kit - 7948 from Cell Signaling Technology Category ELISA Kit

Mouse/Human/Rat Phospho-EIF2S1 (Ser51) ELISA Kit (Cell-Based Phosphorylation ELISA) - LS-F1494 from LifeSpan Bioscience Category ELISA Kit Prices $550.00 Sizes 1 plate

Mouse/Human/Rat EIF2S1 ELISA Kit (Cell-Based ELISA) - LS-F1959 from LifeSpan Bioscience Category ELISA Kit Prices $450.00 Sizes 1 plate

Cell-Based ELISA for detecting phospho-EGFR - RAB0151 from Sigma-Aldrich Prices $402.00 Sizes 1 kt

Cell-Based ELISA for detecting phospho-EGFR (pTyr992) in cultured cell lines - RAB0157 from Sigma-Aldrich Prices $402.00 Sizes 1 kt

Cell-Based ELISA for detecting phospho-EGFR (pTyr1068) in cultured cell lines - RAB0152 from Sigma-Aldrich

Cell-Based ELISA for detecting phospho-EGFR (pTyr845) in cultured cell lines - RAB0155 from Sigma-Aldrich Prices $402.00 Sizes 1 kt

Phospho-EGFR (pTyr1086) ELISA Kit - RAB0167 from Sigma-Aldrich Category ELISA Kit Prices $522.00 Sizes 1 kt

Cell-Based phospho-EGFR ELISA Sampler Kit - RAB0159 from Sigma-Aldrich Category ELISA Kit Prices $878.00 Sizes 1 kt

Phospho-EGFR (pSer1070) ELISA Kit - RAB0161 from Sigma-Aldrich Category ELISA Kit Prices $522.00 Sizes 1 kt

Phospho-EGFR (pTyr1045) and pan-EGFR ELISA Kit - RAB0164 from Sigma-Aldrich Category ELISA Kit Prices $570.00 Sizes 1 kt

Phospho-EGFR (pTyr992) and pan-EGFR ELISA Kit - RAB0170 from Sigma-Aldrich Category ELISA Kit Prices $570.00 Sizes 1 kt

Phospho-EGFR (pSer1070) and pan-EGFR ELISA Kit - RAB0162 from Sigma-Aldrich Category ELISA Kit Prices $570.00 Sizes 1 kt

Human EGFR / ErbB1 ELISA Kit - RAB0160 from Sigma-Aldrich Category ELISA Kit Prices $423.50 Sizes 1 kt

Phospho-EGFR (pTyr1086) and pan-EGFR ELISA Kit - RAB0168 from Sigma-Aldrich Category ELISA Kit Prices $570.00 Sizes 1 kt

Phospho-EGFR (pTyr1045) ELISA Kit - RAB0163 from Sigma-Aldrich Category ELISA Kit Prices $522.00 Sizes 1 kt

Phospho-EGFR (pTyr992) ELISA Kit - RAB0169 from Sigma-Aldrich Category ELISA Kit

Phospho-EGFR (pTyr1068) ELISA Kit - RAB0165 from Sigma-Aldrich Category ELISA Kit Prices $522.00 Sizes 1 kt

Phospho-EGFR (pTyr1068) and pan-EGFR ELISA Kit - RAB0166 from Sigma-Aldrich Category ELISA Kit Prices $570.00 Sizes 1 kt

Eukaryotic translation initiation factor 2 subunit 1 (EIF2S1), Human, ELISA Kit - E01E0373 from ARP American Research Products Category ELISA Kit Prices $535.00, $735.00 Sizes 48 t, 96 t Sensitivity 1.0pg/ml Range 100-2500pg/ml

eIF2alpha Colorimetric Cell-Based ELISA Kit - CB5226 from Assay Biotechnology Category ELISA Kit Prices $380.00, $760.00, $1,140.00 Sizes 1 kit, 2 kits, 3 kits Range > 5000 Cells

eIF2alpha (Phospho-Ser51) Colorimetric Cell-Based ELISA Kit - CBP1538 from Assay Biotechnology Category ELISA Kit Prices $480.00, $960.00, $1,440.00 Sizes 1 kit, 2 kits, 3 kits Range > 5000 Cells

Eukaryotic translation initiation factor 2 subunit 1, ELISA Kit - MBS281320 from MyBioSource Category ELISA Kit Prices $465.00, $790.00, $3,500.00, $6,655.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

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