| Gene Symbol |
EIF2S1
|
| Entrez Gene |
1965
|
| Alt Symbol |
EIF-2, EIF-2A, EIF-2alpha, EIF2, EIF2A
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa
|
| Other Description |
eIF-2-alpha|eukaryotic translation initiation factor 2 subunit 1|eukaryotic translation initiation factor 2 subunit alpha
|
| Swissprots |
P05198
|
| Accessions |
EAW80933 EAW80934 P05198 AK297244 BAG59724 AK312442 BAG35351 BC002513 AAH02513 BX161521 CAD61953 D28379 BAA05745 DQ892151 ABM83077 DQ895347 ABM86273 J02645 AAA52373 U26032 NM_004094 NP_004085
|
| Function |
Functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S preinitiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must exchange with GTP by way of a reaction catalyzed by eIF-2B.
|
| Subcellular Location |
Cytoplasmic granule {ECO:0000250}. Note=The cytoplasmic granules are stress granules which are a dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress. Colocalizes with NANOS3 in the stress granules (By similarity). {ECO:0000250}.
|
| Top Pathways |
Protein processing in endoplasmic reticulum, RNA transport, Hepatitis C, Measles, Influenza A
|