EIF2S1

Gene Symbol EIF2S1
Entrez Gene 1965
Alt Symbol EIF-2, EIF-2A, EIF-2alpha, EIF2, EIF2A
Species Human
Gene Type protein-coding
Description eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa
Other Description eIF-2-alpha|eukaryotic translation initiation factor 2 subunit 1|eukaryotic translation initiation factor 2 subunit alpha
Swissprots P05198
Accessions EAW80933 EAW80934 P05198 AK297244 BAG59724 AK312442 BAG35351 BC002513 AAH02513 BX161521 CAD61953 D28379 BAA05745 DQ892151 ABM83077 DQ895347 ABM86273 J02645 AAA52373 U26032 NM_004094 NP_004085
Function Functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S preinitiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must exchange with GTP by way of a reaction catalyzed by eIF-2B.
Subcellular Location Cytoplasmic granule {ECO:0000250}. Note=The cytoplasmic granules are stress granules which are a dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress. Colocalizes with NANOS3 in the stress granules (By similarity). {ECO:0000250}.
Top Pathways Protein processing in endoplasmic reticulum, RNA transport, Hepatitis C, Measles, Influenza A

Human EIF2S1 gene - orb93546 from Biorbyt

Prices $264.00
Sizes 10 μg
Species Human

Human EIF2S1 ORF clone (NM_004094.4) - CDCB160232 from Creative biogene

Species Human
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