| Gene Symbol |
AP3S1
|
| Entrez Gene |
1176
|
| Alt Symbol |
CLAPS3, Sigma3A
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
adaptor-related protein complex 3, sigma 1 subunit
|
| Other Description |
AP-3 complex sigma-3A subunit|AP-3 complex subunit sigma-1|AP-3 complex subunit sigma-3A|adapter-related protein complex 3 sigma-1 subunit|adapter-related protein complex 3 subunit sigma-1|adaptor-related protein complex 3 subunit sigma-1|clathrin-associated/assembly/adapter protein, small 3|clathrin-associated/assembly/adaptor protein, small 3 (22kD)|sigma-3A-adaptin|sigma-adaptin 3a|sigma3A-adaptin
|
| Swissprots |
Q53XL4 O00676 O00721 Q6ICQ2 O00727 O00647 Q92572
|
| Accessions |
EAW48952 EAW48953 Q92572 AK124911 AK126876 AK311843 BAG34785 BC000804 AAH00804 BC012614 BI600357 BT009833 AAP88835 BX647735 CR450341 CAG29337 D63643 BAA09798 DQ891198 ABM82124 DQ894381 ABM85307 U91932 AAD03779 X99458 CAA67823 XM_011543135 XP_011541437 XM_011543136 XP_011541438 XM_011543137 XP_011541439 XM_011543138 XP_011541440 NM_001002924 NM_001284 NP_001275
|
| Function |
Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals.
|
| Subcellular Location |
Golgi apparatus. Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Note=Component of the coat surrounding the cytoplasmic face of coated vesicles located at the Golgi complex.
|
| Tissue Specificity |
Present in all adult tissues examined. {ECO:0000269|PubMed:8697810, ECO:0000269|PubMed:9118953, ECO:0000269|PubMed:9151686}.
|
| Top Pathways |
Lysosome
|