| Gene Symbol |
Itgae
|
| Entrez Gene |
16407
|
| Alt Symbol |
A530055J10, CD103, aM290, alpha-E1, alpha-M290
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
integrin alpha E, epithelial-associated
|
| Other Description |
integrin alpha M290|integrin alpha-E
|
| Swissprots |
Q60677 B1AUD5
|
| Accessions |
AAK30302 BAB00639 EDL12709 Q60677 AK040983 BAC30769 AK154021 BAE32321 AV204610 BC150690 AAI50691 BF453582 CF983010 DQ386608 ABD49099 U12236 AAC52142 XM_006536289 XP_006536352 NM_172944 NP_766532 NM_008399 NP_032425
|
| Function |
Integrin alpha-E/beta-7 is a receptor for E-cadherin. It mediates adhesion of intra-epithelial T-lymphocytes to epithelial cell monolayers. Mice expressing a null mutation of the alpha-E subunit gene exhibit a marked reduction in the numbers of intraepithelial lymphocytes in the gut and in the development of gut-associated lymphoid aggregates, supporting a specific role for this integrin in mediating retention of lymphocytes in the intestinal wall.
|
| Subcellular Location |
Membrane; Single-pass type I membrane protein.
|
| Top Pathways |
Regulation of actin cytoskeleton
|