Gene Symbol | Itgae |
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Entrez Gene | 16407 |
Alt Symbol | A530055J10, CD103, aM290, alpha-E1, alpha-M290 |
Species | Mouse |
Gene Type | protein-coding |
Description | integrin alpha E, epithelial-associated |
Other Description | integrin alpha M290|integrin alpha-E |
Swissprots | Q60677 B1AUD5 |
Accessions | AAK30302 BAB00639 EDL12709 Q60677 AK040983 BAC30769 AK154021 BAE32321 AV204610 BC150690 AAI50691 BF453582 CF983010 DQ386608 ABD49099 U12236 AAC52142 XM_006536289 XP_006536352 NM_172944 NP_766532 NM_008399 NP_032425 |
Function | Integrin alpha-E/beta-7 is a receptor for E-cadherin. It mediates adhesion of intra-epithelial T-lymphocytes to epithelial cell monolayers. Mice expressing a null mutation of the alpha-E subunit gene exhibit a marked reduction in the numbers of intraepithelial lymphocytes in the gut and in the development of gut-associated lymphoid aggregates, supporting a specific role for this integrin in mediating retention of lymphocytes in the intestinal wall. |
Subcellular Location | Membrane; Single-pass type I membrane protein. |
Top Pathways | Regulation of actin cytoskeleton |
Integrin αE CRISPR/Cas9 KO Plasmid (m) - sc-421166 from Santa Cruz Biotechnology
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Integrin αE HDR Plasmid (m) - sc-421166-HDR from Santa Cruz Biotechnology
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Integrin αE Double Nickase Plasmid (m) - sc-421166-NIC from Santa Cruz Biotechnology
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Integrin αE Double Nickase Plasmid (m2) - sc-421166-NIC-2 from Santa Cruz Biotechnology
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Integrin αE CRISPR Activation Plasmid (m) - sc-421166-ACT from Santa Cruz Biotechnology
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Integrin αE CRISPR Activation Plasmid (m2) - sc-421166-ACT-2 from Santa Cruz Biotechnology
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Integrin αE Lentiviral Activation Particles (m) - sc-421166-LAC from Santa Cruz Biotechnology
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Integrin αE Lentiviral Activation Particles (m2) - sc-421166-LAC-2 from Santa Cruz Biotechnology
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Integrin αE siRNA (m) - sc-43132 from Santa Cruz Biotechnology
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Integrin αE shRNA Plasmid (m) - sc-43132-SH from Santa Cruz Biotechnology
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Integrin αE shRNA (m) Lentiviral Particles - sc-43132-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EMU053941 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN33993 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND33993 from Sigma-Aldrich
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ITGAE siRNA (Mouse) - CRM2115 from Cohesion Biosciences
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ITGAE - MBS8204990 from MyBioSource
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shRNA set against Mouse ITGAE (NM_008399.2) - SHH321285 from Creative biogene
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shRNA set against Mouse Itgae(NM_172944.2) - SHL181794 from Creative biogene
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ITGAE shRNA Plasmid (Mouse) - CHM2115 from Cohesion Biosciences
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ITGAE miRNA 3'UTR clone - MiUTR1M-06139 from Creative biogene
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