| Gene Symbol | Vcam1 |
|---|---|
| Entrez Gene | 25361 |
| Alt Symbol | VCAM1B |
| Species | Rat |
| Gene Type | protein-coding |
| Description | vascular cell adhesion molecule 1 |
| Other Description | V-CAM 1|VCAM-1|vascular cell adhesion protein 1 |
| Swissprots | P29534 Q63669 Q5FVS3 |
| Accessions | EDL82023 P29534 BC089812 AAH89812 M84488 AAA42332 X63722 CAA45254 NM_012889 NP_037021 |
| Function | Important in cell-cell recognition. Appears to function in leukocyte-endothelial cell adhesion. Interacts with integrin alpha-4/beta-1 (ITGA4/ITGB1) on leukocytes, and mediates both adhesion and signal transduction. The VCAM1/ITGA4/ITGB1 interaction may play a pathophysiologic role both in immune responses and in leukocyte emigration to sites of inflammation. |
| Subcellular Location | Membrane; Single-pass type I membrane protein. |
| Tissue Specificity | Expressed on inflamed vascular endothelium, as well as on macrophage-like and dendritic cell types in both normal and inflamed tissue. |
| Top Pathways | Leukocyte transendothelial migration, Cell adhesion molecules (CAMs), Malaria, African trypanosomiasis, HTLV-I infection |