| Gene Symbol | Vcam1 |
|---|---|
| Entrez Gene | 25361 |
| Alt Symbol | VCAM1B |
| Species | Rat |
| Gene Type | protein-coding |
| Description | vascular cell adhesion molecule 1 |
| Other Description | V-CAM 1|VCAM-1|vascular cell adhesion protein 1 |
| Swissprots | P29534 Q63669 Q5FVS3 |
| Accessions | EDL82023 P29534 BC089812 AAH89812 M84488 AAA42332 X63722 CAA45254 NM_012889 NP_037021 |
| Function | Important in cell-cell recognition. Appears to function in leukocyte-endothelial cell adhesion. Interacts with integrin alpha-4/beta-1 (ITGA4/ITGB1) on leukocytes, and mediates both adhesion and signal transduction. The VCAM1/ITGA4/ITGB1 interaction may play a pathophysiologic role both in immune responses and in leukocyte emigration to sites of inflammation. |
| Subcellular Location | Membrane; Single-pass type I membrane protein. |
| Tissue Specificity | Expressed on inflamed vascular endothelium, as well as on macrophage-like and dendritic cell types in both normal and inflamed tissue. |
| Top Pathways | Leukocyte transendothelial migration, Cell adhesion molecules (CAMs), Malaria, African trypanosomiasis, HTLV-I infection |
CompoZr® Knockout ZFN Kit - CKOZFN65126 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND65126 from Sigma-Aldrich
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VCAM1 siRNA (Rat) - CRR0612 from Cohesion Biosciences
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VCAM1 - MBS8223189 from MyBioSource
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shRNA set against Rat VCAM1 (NM_012889.1) - SHH442428 from Creative biogene
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shRNA set against Rat Vcam1(NM_012889.1) - SHL122140 from Creative biogene
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Rat VCAM1 siRNA - orb295461 from Biorbyt
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VCAM1 shRNA Plasmid (Rat) - CHR0612 from Cohesion Biosciences
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VCAM1 miRNA 3'UTR clone - MiUTR1R-08505 from Creative biogene
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