Tgfbr2

Gene Symbol	Tgfbr2
Entrez Gene	21813
Alt Symbol	1110020H15Rik, AU042018, DNIIR, RIIDN, TBR-II, TbetaR-II, TbetaRII
Species	Mouse
Gene Type	protein-coding
Description	transforming growth factor, beta receptor II
Other Description	TGF-beta receptor II|TGF-beta receptor type II|TGF-beta receptor type-2|TGF-beta type II receptor|TGFR-2|transforming growth factor-beta receptor type II
Swissprots	Q62312 Q63947
Accessions	AAF27281 EDL09274 EDL09275 Q62312 AF406755 AAK98605 AK003861 AK043619 BAC31597 AK046561 BAC32788 AK053793 BAC35526 AK090393 AK148167 BAE28387 AK159327 BAE34993 BC016262 AAH16262 BC052629 CO039384 S69114 AAB30100 NM_009371 NP_033397 NM_029575 NP_083851
Function	Transmembrane serine/threonine kinase forming with the TGF-beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound to the cytokine dimer results in the phosphorylation and the activation of TGFRB1 by the constitutively active TGFBR2. Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of
Subcellular Location	Cell membrane; Single-pass type I membrane protein.
Tissue Specificity	Widely expressed in adult. Expressed primarily in mesenchyme and epidermis of the midgestational fetus.
Top Pathways	TGF-beta signaling pathway, Hippo signaling pathway, Adherens junction, Chronic myeloid leukemia, HTLV-I infection

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

TGFβ RII (I-20) - sc-33931 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

TGFβ RII (S-20) - sc-33932 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

TGF-beta RII Antibody (RM0132-6G11) - NBP1-22508 from Novus Biologicals Prices $349.00 Sizes 100 µg Host Rat Clonality Monoclonal Clone RM0132-6G11

TGF-beta RII Antibody [PE] - FAB532P-025 from Novus Biologicals Host Goat Clonality Polyclonal

TGF-beta RII Antibody [Alexa Fluor (R) 700] - FAB532N-025 from Novus Biologicals Host Goat Clonality Polyclonal

TGF-beta RII Antibody [Fluorescein] - FAB532F-025 from Novus Biologicals Host Goat Clonality Polyclonal

TGF-beta RII Antibody [PerCP] - FAB532C-025 from Novus Biologicals Host Goat Clonality Polyclonal

TGF-beta RII Antibody [Allophycocyanin] - FAB532A-025 from Novus Biologicals Host Goat Clonality Polyclonal

ANTI-MOUSE TGFBR2 (C-TERM) antibody produced in rabbit - SAB1302520 from Sigma-Aldrich Prices $326.50 Sizes 100 µg Host Rabbit Clonality Polyclonal

Mouse-Tgfbr2-Antibody-C-term - AP17322b from Abgent, a WuXi AppTec company Prices $99.00, $295.00 Sizes 80 µl, 400 µl Host Rabbit Clonality Polyclonal

Mouse Tgfbr2 Antibody - C-terminal region (OAAB12753) - OAAB12753 from Aviva Systems Biology Prices $289.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

TGFBR2 antibody - 70R-35906 from Fitzgerald Prices $275.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

TGFBR2 antibody (Ser225/250) - 70R-36861 from Fitzgerald Prices $275.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

TGF beta Receptor 2 antibody - 70R-30768 from Fitzgerald Prices $275.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

TGFBR2 Antibody - abx026476 from Abbexa Host Rabbit Clonality Polyclonal

TGF beta R2, Monoclonal Antibody - MBS690878 from MyBioSource Prices $460.00 Sizes 100 µg Host Rat Clonality Monoclonal Clone (6G11)

TGFBR2 antibody - 70R-51655 from Fitzgerald Prices $475.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Tgfbr2, Polyclonal Antibody - MBS9211747 from MyBioSource Prices $155.00, $340.00 Sizes 80 µl, 400 µl Host Rabbit Clonality Polyclonal

anti-TGF-b Receptor II antibody - ARG20381 from Arigo Biolaboratories Host Rabbit Clonality Polyclonal

Transforming Growth Factor Beta Receptor II, Polyclonal Antibody - MBS2027588 from MyBioSource Prices $135.00, $165.00, $245.00, $325.00, $505.00, $1,215.00 Sizes 10 µg, 20 µg, 50 µg, 100 µg, 200 µg, 1 mg Host Rabbit Clonality Polyclonal

Tgfbr2 Antibody (F45533) - F45533 from NSJ Bioreagent Prices $125.00, $299.00 Sizes 80 µl (In 1X PBS, pH 7.4, with 0.09% sodium azide), 400 µl (In 1X PBS, pH 7.4, with 0.09% sodium azide) Host Rabbit Clonality Polyclonal

Mouse Tgfbr2 Antibody - 59-113 from ProSci Prices $375.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

TGFBR2 Polyclonal Antibody - A11788 from ARP American Research Products Prices $130.00, $220.00, $380.00 Sizes 50 µl, 100 µl, 200 µl Clonality Polyclonal

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