Tgfbr2

Gene Symbol	Tgfbr2
Entrez Gene	21813
Alt Symbol	1110020H15Rik, AU042018, DNIIR, RIIDN, TBR-II, TbetaR-II, TbetaRII
Species	Mouse
Gene Type	protein-coding
Description	transforming growth factor, beta receptor II
Other Description	TGF-beta receptor II|TGF-beta receptor type II|TGF-beta receptor type-2|TGF-beta type II receptor|TGFR-2|transforming growth factor-beta receptor type II
Swissprots	Q62312 Q63947
Accessions	AAF27281 EDL09274 EDL09275 Q62312 AF406755 AAK98605 AK003861 AK043619 BAC31597 AK046561 BAC32788 AK053793 BAC35526 AK090393 AK148167 BAE28387 AK159327 BAE34993 BC016262 AAH16262 BC052629 CO039384 S69114 AAB30100 NM_009371 NP_033397 NM_029575 NP_083851
Function	Transmembrane serine/threonine kinase forming with the TGF-beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound to the cytokine dimer results in the phosphorylation and the activation of TGFRB1 by the constitutively active TGFBR2. Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of
Subcellular Location	Cell membrane; Single-pass type I membrane protein.
Tissue Specificity	Widely expressed in adult. Expressed primarily in mesenchyme and epidermis of the midgestational fetus.
Top Pathways	TGF-beta signaling pathway, Hippo signaling pathway, Adherens junction, Chronic myeloid leukemia, HTLV-I infection

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

TGF-beta receptor type-2 (TGFBR2), Mouse, ELISA Kit - CSB-EL023452MO from ARP American Research Products Category ELISA Kit Prices $495.00, $695.00, $696.00, $699.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t

TGF-beta receptor type-2 (TGFBR2), Mouse, ELISA Kit - E03T0684 from ARP American Research Products Category ELISA Kit Prices $535.00, $735.00 Sizes 48 t, 96 t

TGF-beta receptor type-2, Tgfbr2, Mouse, ELISA Kit - E9935m from ARP American Research Products Category ELISA Kit Prices $660.00 Sizes 96 t

Transforming Growth Factor Beta Receptor II (TGFbR2), Mouse, ELISA Kit - SEC972Mu from ARP American Research Products Category ELISA Kit Prices $740.00 Sizes 96 t Sensitivity 0.105ng/mL Range 0.312-20ng/mL

transforming growth factor, beta receptor II (70/80kDa) , ELISA Kit - MBS938046 from MyBioSource Category ELISA Kit Prices $250.00, $495.00, $710.00, $2,705.00, $5,145.00 Sizes 24 -strip-wells (Limit 1), 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity The minimum detectable dose of mouse TGFBR2 is typically less than 19.5 pg/ml. The sensitivity of this assay, or Lower Limit of Detection (LLD) was defined as the lowest protein concentration that could be differentiated from zero. It was determined the mean O.D value of 20 replicates of the zero standard added by their three standard deviations. Range 78.1 pg/ml-5000 pg/ml.

Mouse TGF-beta receptor type-2(TGFBR2) ELISA kit - CSB-EL023452MO from Cusabio Category ELISA Kit Sensitivity 19.5 pg/ml Range 78 pg/ml-5000 pg/ml

Mouse TGFbR2 ELISA Kit - abx154748 from Abbexa Category ELISA Kit Sensitivity 0.134 ng/ml Range 0.313 ng/ml - 20 ng/ml

Transforming Growth Factor Beta Receptor II (TGFbR2), Mouse, ELISA Kit - DL-TGFbR2-Mu from ARP American Research Products Category ELISA Kit Prices $685.00 Sizes 96 t Range 0.312-20 ng/mL

Mouse TGFbR2 ELISA Kit - abx572921 from Abbexa Category ELISA Kit Sensitivity 0.105 ng/ml Range 0.313 ng/ml - 20 ng/ml

Mouse TGF-beta receptor type-2(TGFBR2) ELISA Kit - EKC37907 from Biomatik Category ELISA Kit Prices $705.00, $2,820.00, $5,287.50 Sizes 96 t, 5x96t, 10x96t Sensitivity 19.5 pg/ml Range 78 pg/ml-5000 pg/ml

Mouse TGF-beta receptor type-2 ELISA Kit - EKE54354 from Biomatik Category ELISA Kit Prices $759.00, $3,225.75, $6,072.00 Sizes 96 t, 5x96t, 10x96t Range 15.6-1000 pg/mL

TGFBR2 ELISA Kit (Mouse) : 96 Wells (OKEH02032) - OKEH02032 from Aviva Systems Biology Category ELISA Kit Prices $450.00 Sizes 96 wells Sensitivity < 10 pg/mL Range 15.6 - 1000 pg/mL

Mouse Tgfbr2 ELISA Kit - E069893 from Biobool Category ELISA Kit

Mouse TGF-beta receptor type-2 ELISA Kit - EK5069 from Signalway Antibody Category ELISA Kit Prices $659.00 Sizes 1x96t Range 15.6-1000 pg/mL

Mouse TGF-beta receptor type-2 (TGFBR2) ELISA Kit - AE17212MO from ARP American Research Products Category ELISA Kit Prices $549.00 Sizes 96 t

TGF-beta receptor type-2, ELISA Kit - MBS2885129 from MyBioSource Category ELISA Kit Prices $430.00, $570.00, $2,515.00, $4,520.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Range 15.6-1000 pg/mL

TGF-beta receptor type-2, ELISA Kit - MBS9428895 from MyBioSource Category ELISA Kit Prices $605.00 Sizes 96 tests Range 15.6-1000 pg/mL

Transforming Growth Factor Beta Receptor II (TGFbR2), ELISA Kit - MBS451357 from MyBioSource Category ELISA Kit Prices $385.00, $505.00, $2,200.00, $4,265.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.105ng/mL Range 0.312-20ng/mL

Mouse TGF beta Receptor 2 ELISA Kit - orb408687 from Biorbyt Category ELISA Kit Sensitivity 19.5 pg/ml Range 78 pg/ml-5000 pg/ml

Mouse TGF-beta receptor type-2 (TGFBR2) ELISA kit - EKC41968 from Biomatik Category ELISA Kit Prices $709.00 Sizes 96 tests Sensitivity 19.5 pg/mL Range 78 pg/mL-5000 pg/mL

Search more