| Gene Symbol |
Tgfbr2
|
| Entrez Gene |
21813
|
| Alt Symbol |
1110020H15Rik, AU042018, DNIIR, RIIDN, TBR-II, TbetaR-II, TbetaRII
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
transforming growth factor, beta receptor II
|
| Other Description |
TGF-beta receptor II|TGF-beta receptor type II|TGF-beta receptor type-2|TGF-beta type II receptor|TGFR-2|transforming growth factor-beta receptor type II
|
| Swissprots |
Q62312 Q63947
|
| Accessions |
AAF27281 EDL09274 EDL09275 Q62312 AF406755 AAK98605 AK003861 AK043619 BAC31597 AK046561 BAC32788 AK053793 BAC35526 AK090393 AK148167 BAE28387 AK159327 BAE34993 BC016262 AAH16262 BC052629 CO039384 S69114 AAB30100 NM_009371 NP_033397 NM_029575 NP_083851
|
| Function |
Transmembrane serine/threonine kinase forming with the TGF-beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound to the cytokine dimer results in the phosphorylation and the activation of TGFRB1 by the constitutively active TGFBR2. Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of
|
| Subcellular Location |
Cell membrane; Single-pass type I membrane protein.
|
| Tissue Specificity |
Widely expressed in adult. Expressed primarily in mesenchyme and epidermis of the midgestational fetus.
|
| Top Pathways |
TGF-beta signaling pathway, Hippo signaling pathway, Adherens junction, Chronic myeloid leukemia, HTLV-I infection
|