Tgfbr2

Gene Symbol Tgfbr2
Entrez Gene 21813
Alt Symbol 1110020H15Rik, AU042018, DNIIR, RIIDN, TBR-II, TbetaR-II, TbetaRII
Species Mouse
Gene Type protein-coding
Description transforming growth factor, beta receptor II
Other Description TGF-beta receptor II|TGF-beta receptor type II|TGF-beta receptor type-2|TGF-beta type II receptor|TGFR-2|transforming growth factor-beta receptor type II
Swissprots Q62312 Q63947
Accessions AAF27281 EDL09274 EDL09275 Q62312 AF406755 AAK98605 AK003861 AK043619 BAC31597 AK046561 BAC32788 AK053793 BAC35526 AK090393 AK148167 BAE28387 AK159327 BAE34993 BC016262 AAH16262 BC052629 CO039384 S69114 AAB30100 NM_009371 NP_033397 NM_029575 NP_083851
Function Transmembrane serine/threonine kinase forming with the TGF-beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound to the cytokine dimer results in the phosphorylation and the activation of TGFRB1 by the constitutively active TGFBR2. Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of
Subcellular Location Cell membrane; Single-pass type I membrane protein.
Tissue Specificity Widely expressed in adult. Expressed primarily in mesenchyme and epidermis of the midgestational fetus.
Top Pathways TGF-beta signaling pathway, Hippo signaling pathway, Adherens junction, Chronic myeloid leukemia, HTLV-I infection

Mouse-Tgfbr2-Antibody-C-term-Blocking-Peptide - BP17322b from Abgent, a WuXi AppTec company

Category Peptide
Prices $80.00
Sizes 100 µg
Species Mouse

Recombinant Mouse TGF-beta RII/(mouse) Fc Chimera, CF - 1600-R2-050 from R&D Systems

Category Protein
Source Mouse myeloma cell line, NS0-derived

Recombinant Mouse TGF-beta RII/(human) Fc Chimera, CF - 532-R2-050 from R&D Systems

Category Protein
Source Mouse myeloma cell line, NS0-derived

Recombinant Mouse Transforming Growth Factor, Beta Receptor II - Tgfbr2-1778M from Creative Biomart

Category Protein
Source NSO Cells .

Recombinant Mouse TGF-beta receptor type-2(Tgfbr2) - CSB-YP720297MO CSB-EP720297MO CSB-BP720297MO CSB-MP720297MO from Cusabio

Category Protein
Source Yeast or E.coli or Baculovirus or Mammalian cell
Species Mouse

Recombinant Mouse TGF-beta RII/(mouse) Fc Chimera, CF - 1600-R2 from R&D Systems

Category Protein
Prices $349.00
Sizes 50 µg
Source Mouse myeloma cell line, NS0-derived Mouse TGF-beta RII (Ile24 - Asp184) Accession # Q62312 IEGRMDP Mouse IgG 2a (Glu98 - Lys330) N-terminus C-terminus
Species Mouse

Recombinant Mouse TGF-beta RII/(human) Fc Chimera, CF - 532-R2 from R&D Systems

Category Protein
Prices $349.00
Sizes 50 µg
Source Mouse myeloma cell line, NS0-derived Mouse TGF-beta RII (Ile24-Asp184) Accession # Q62312.1 IEGRMD Human IgG 1 (Pro100-Lys330) N-terminus C-terminus
Species Mouse

TGF-beta receptor type-2 (Tgfbr2), Recombinant Protein - MBS1330265 from MyBioSource

Category Protein
Prices $905.00, $905.00, $1,125.00, $1,125.00, $1,335.00, $1,335.00, $1,790.00, $1,790.00
Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell)
Source E Coli or Yeast or Baculovirus or Mammalian Cell
Species Mouse

Mouse Transforming Growth Factor-beta Receptor Type II protein - orb334455 from Biorbyt

Category Protein
Prices $230.00, $349.00, $1,675.00, $2,372.00
Sizes 10 μg, 50 μg, 500 μg, 1 mg
Species Mouse

Mouse Transforming Growth Factor-beta Receptor Type II protein - orb334456 from Biorbyt

Category Protein
Prices $230.00, $349.00, $1,675.00, $2,372.00
Sizes 10 μg, 50 μg, 500 μg, 1 mg
Species Mouse

TGFBR2 Recombinant Protein (OPCD07394) - OPCD07394 from Aviva Systems Biology

Category Protein
Source E.coli
Species Mouse
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