| Gene Symbol |
S1pr4
|
| Entrez Gene |
13611
|
| Alt Symbol |
Edg6, Lpc1, S1p4
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
sphingosine-1-phosphate receptor 4
|
| Other Description |
S1P receptor Edg-6|S1p receptor 4|endothelial differentiation G-protein coupled receptor 6|endothelial differentiation G-protein-coupled receptor 6|lysophospholipid receptor C1|sphingosine 1-phosphate receptor 4|sphingosine 1-phosphate receptor Edg-6
|
| Swissprots |
Q8K1R9 Q8C6E2 Q9Z0L1 Q3U4H3
|
| Accessions |
CAD33254 EDL31402 Q9Z0L1 AJ006074 CAA06847 AK075854 AK154242 BAE32458 BC107000 AAI07001 NM_010102 NP_034232
|
| Function |
Receptor for the lysosphingolipid sphingosine 1- phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. May be involved in cell migration processes that are specific for lymphocytes (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cell membrane; Multi-pass membrane protein.
|
| Tissue Specificity |
Specifically expressed in fetal and adult lymphoid and hematopoietic tissue. Expressed in lung, spleen, thymus and lymph node but absent in other non-lymphatic tissue. Coexpressed with GNA15 at the same relative levels in all tissues examined, with the highest levels in adult spleen and lung. {ECO:0000269|PubMed:12401211}.
|
| Top Pathways |
Sphingolipid signaling pathway, Neuroactive ligand-receptor interaction
|