| Gene Symbol | S1pr4 |
|---|---|
| Entrez Gene | 13611 |
| Alt Symbol | Edg6, Lpc1, S1p4 |
| Species | Mouse |
| Gene Type | protein-coding |
| Description | sphingosine-1-phosphate receptor 4 |
| Other Description | S1P receptor Edg-6|S1p receptor 4|endothelial differentiation G-protein coupled receptor 6|endothelial differentiation G-protein-coupled receptor 6|lysophospholipid receptor C1|sphingosine 1-phosphate receptor 4|sphingosine 1-phosphate receptor Edg-6 |
| Swissprots | Q8K1R9 Q8C6E2 Q9Z0L1 Q3U4H3 |
| Accessions | CAD33254 EDL31402 Q9Z0L1 AJ006074 CAA06847 AK075854 AK154242 BAE32458 BC107000 AAI07001 NM_010102 NP_034232 |
| Function | Receptor for the lysosphingolipid sphingosine 1- phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. May be involved in cell migration processes that are specific for lymphocytes (By similarity). {ECO:0000250}. |
| Subcellular Location | Cell membrane; Multi-pass membrane protein. |
| Tissue Specificity | Specifically expressed in fetal and adult lymphoid and hematopoietic tissue. Expressed in lung, spleen, thymus and lymph node but absent in other non-lymphatic tissue. Coexpressed with GNA15 at the same relative levels in all tissues examined, with the highest levels in adult spleen and lung. {ECO:0000269|PubMed:12401211}. |
| Top Pathways | Sphingolipid signaling pathway, Neuroactive ligand-receptor interaction |