Gene Symbol | S1pr4 |
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Entrez Gene | 13611 |
Alt Symbol | Edg6, Lpc1, S1p4 |
Species | Mouse |
Gene Type | protein-coding |
Description | sphingosine-1-phosphate receptor 4 |
Other Description | S1P receptor Edg-6|S1p receptor 4|endothelial differentiation G-protein coupled receptor 6|endothelial differentiation G-protein-coupled receptor 6|lysophospholipid receptor C1|sphingosine 1-phosphate receptor 4|sphingosine 1-phosphate receptor Edg-6 |
Swissprots | Q8K1R9 Q8C6E2 Q9Z0L1 Q3U4H3 |
Accessions | CAD33254 EDL31402 Q9Z0L1 AJ006074 CAA06847 AK075854 AK154242 BAE32458 BC107000 AAI07001 NM_010102 NP_034232 |
Function | Receptor for the lysosphingolipid sphingosine 1- phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. May be involved in cell migration processes that are specific for lymphocytes (By similarity). {ECO:0000250}. |
Subcellular Location | Cell membrane; Multi-pass membrane protein. |
Tissue Specificity | Specifically expressed in fetal and adult lymphoid and hematopoietic tissue. Expressed in lung, spleen, thymus and lymph node but absent in other non-lymphatic tissue. Coexpressed with GNA15 at the same relative levels in all tissues examined, with the highest levels in adult spleen and lung. {ECO:0000269|PubMed:12401211}. |
Top Pathways | Sphingolipid signaling pathway, Neuroactive ligand-receptor interaction |
EDG-6 CRISPR/Cas9 KO Plasmid (m) - sc-420106 from Santa Cruz Biotechnology
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EDG-6 HDR Plasmid (m) - sc-420106-HDR from Santa Cruz Biotechnology
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EDG-6 Double Nickase Plasmid (m) - sc-420106-NIC from Santa Cruz Biotechnology
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EDG-6 Double Nickase Plasmid (m2) - sc-420106-NIC-2 from Santa Cruz Biotechnology
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EDG-6 CRISPR Activation Plasmid (m) - sc-420106-ACT from Santa Cruz Biotechnology
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EDG-6 CRISPR Activation Plasmid (m2) - sc-420106-ACT-2 from Santa Cruz Biotechnology
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EDG-6 Lentiviral Activation Particles (m) - sc-420106-LAC from Santa Cruz Biotechnology
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EDG-6 Lentiviral Activation Particles (m2) - sc-420106-LAC-2 from Santa Cruz Biotechnology
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EDG-6 siRNA (m) - sc-143296 from Santa Cruz Biotechnology
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EDG-6 shRNA Plasmid (m) - sc-143296-SH from Santa Cruz Biotechnology
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EDG-6 shRNA (m) Lentiviral Particles - sc-143296-V from Santa Cruz Biotechnology
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CompoZr® Knockout ZFN Kit - CKOZFN40665 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND40665 from Sigma-Aldrich
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S1PR4 siRNA (Mouse) - CRM1130 from Cohesion Biosciences
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S1PR4 - MBS8222936 from MyBioSource
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shRNA set against Mouse S1PR4 (NM_010102.2) - SHH401364 from Creative biogene
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Mouse S1PR4 siRNA - orb280606 from Biorbyt
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S1PR4 shRNA Plasmid (Mouse) - CHM1130 from Cohesion Biosciences
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