| Gene Symbol |
Epor
|
| Entrez Gene |
13857
|
| Alt Symbol |
-
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
erythropoietin receptor
|
| Other Description |
EPO-R
|
| Swissprots |
Q63852 P14753
|
| Accessions |
AAA37572 AAA37582 CAA37248 EDL25236 P14753 AK010968 AK139031 BAE23871 BB842890 BC003953 AAH03953 BC046282 AAH46282 J04843 AAA37571 XM_006509998 XP_006510061 NM_010149 NP_034279
|
| Function |
Receptor for erythropoietin. Mediates erythropoietin- induced erythroblast proliferation and differentiation. Upon EPO stimulation, EPOR dimerizes triggering the JAK2/STAT5 signaling cascade. In some cell types, can also activate STAT1 and STAT3. May also activate the LYN tyrosine kinase. {ECO:0000269|PubMed:8382775, ECO:0000269|PubMed:8617735}.
|
| Subcellular Location |
Isoform EPOR-F: Cell membrane; Single-pass type I membrane protein.
|
| Tissue Specificity |
Expressed in relatively mature erythroid progenitor cells and in EPO-responsive erythroleukemia cells.
|
| Top Pathways |
Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway, Hematopoietic cell lineage, PI3K-Akt signaling pathway
|