Gene Symbol | Epor |
---|---|
Entrez Gene | 13857 |
Alt Symbol | - |
Species | Mouse |
Gene Type | protein-coding |
Description | erythropoietin receptor |
Other Description | EPO-R |
Swissprots | Q63852 P14753 |
Accessions | AAA37572 AAA37582 CAA37248 EDL25236 P14753 AK010968 AK139031 BAE23871 BB842890 BC003953 AAH03953 BC046282 AAH46282 J04843 AAA37571 XM_006509998 XP_006510061 NM_010149 NP_034279 |
Function | Receptor for erythropoietin. Mediates erythropoietin- induced erythroblast proliferation and differentiation. Upon EPO stimulation, EPOR dimerizes triggering the JAK2/STAT5 signaling cascade. In some cell types, can also activate STAT1 and STAT3. May also activate the LYN tyrosine kinase. {ECO:0000269|PubMed:8382775, ECO:0000269|PubMed:8617735}. |
Subcellular Location | Isoform EPOR-F: Cell membrane; Single-pass type I membrane protein. |
Tissue Specificity | Expressed in relatively mature erythroid progenitor cells and in EPO-responsive erythroleukemia cells. |
Top Pathways | Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway, Hematopoietic cell lineage, PI3K-Akt signaling pathway |