Gene Symbol | Epor |
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Entrez Gene | 13857 |
Alt Symbol | - |
Species | Mouse |
Gene Type | protein-coding |
Description | erythropoietin receptor |
Other Description | EPO-R |
Swissprots | Q63852 P14753 |
Accessions | AAA37572 AAA37582 CAA37248 EDL25236 P14753 AK010968 AK139031 BAE23871 BB842890 BC003953 AAH03953 BC046282 AAH46282 J04843 AAA37571 XM_006509998 XP_006510061 NM_010149 NP_034279 |
Function | Receptor for erythropoietin. Mediates erythropoietin- induced erythroblast proliferation and differentiation. Upon EPO stimulation, EPOR dimerizes triggering the JAK2/STAT5 signaling cascade. In some cell types, can also activate STAT1 and STAT3. May also activate the LYN tyrosine kinase. {ECO:0000269|PubMed:8382775, ECO:0000269|PubMed:8617735}. |
Subcellular Location | Isoform EPOR-F: Cell membrane; Single-pass type I membrane protein. |
Tissue Specificity | Expressed in relatively mature erythroid progenitor cells and in EPO-responsive erythroleukemia cells. |
Top Pathways | Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway, Hematopoietic cell lineage, PI3K-Akt signaling pathway |
EpoR CRISPR/Cas9 KO Plasmid (m) - sc-420210 from Santa Cruz Biotechnology
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EpoR HDR Plasmid (m) - sc-420210-HDR from Santa Cruz Biotechnology
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EpoR Double Nickase Plasmid (m) - sc-420210-NIC from Santa Cruz Biotechnology
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EpoR Double Nickase Plasmid (m2) - sc-420210-NIC-2 from Santa Cruz Biotechnology
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EpoR CRISPR Activation Plasmid (m) - sc-420210-ACT from Santa Cruz Biotechnology
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EpoR CRISPR Activation Plasmid (m2) - sc-420210-ACT-2 from Santa Cruz Biotechnology
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EpoR Lentiviral Activation Particles (m) - sc-420210-LAC from Santa Cruz Biotechnology
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EpoR Lentiviral Activation Particles (m2) - sc-420210-LAC-2 from Santa Cruz Biotechnology
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EpoR siRNA (m) - sc-39959 from Santa Cruz Biotechnology
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EpoR shRNA Plasmid (m) - sc-39959-SH from Santa Cruz Biotechnology
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EpoR shRNA (m) Lentiviral Particles - sc-39959-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EMU020191 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN30716 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND30716 from Sigma-Aldrich
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EPOR siRNA (Mouse) - CRM1230 from Cohesion Biosciences
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EPOR - MBS8209182 from MyBioSource
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shRNA set against Mouse Epo (NM_010149.3) - SHH286609 from Creative biogene
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shRNA set against Mouse Epor(NM_010149.3) - SHH036929 from Creative biogene
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EPOR shRNA Plasmid (Mouse) - CHM1230 from Cohesion Biosciences
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EPOR miRNA 3'UTR clone - MiUTR1M-04440 from Creative biogene
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