CSPG4

Gene Symbol	CSPG4
Entrez Gene	1464
Alt Symbol	HMW-MAA, MCSP, MCSPG, MEL-CSPG, MSK16, NG2
Species	Human
Gene Type	protein-coding
Description	chondroitin sulfate proteoglycan 4
Other Description	chondroitin sulfate proteoglycan 4 (melanoma-associated)|chondroitin sulfate proteoglycan NG2|melanoma chondroitin sulfate proteoglycan|melanoma-associated chondroitin sulfate proteoglycan
Swissprots	Q6UVK1 Q92675 D3DW77
Accessions	EAW99239 EAW99240 Q6UVK1 AY359468 AAQ62842 BC033194 BC128110 AAI28111 BC172270 AAI72270 BC172576 AAI72576 BP363063 BQ679485 CA428796 CA438367 CB044012 X96753 CAA65529 NM_001897 NP_001888
Function	Proteoglycan playing a role in cell proliferation and migration which stimulates endothelial cells motility during microvascular morphogenesis. May also inhibit neurite outgrowth and growth cone collapse during axon regeneration. Cell surface receptor for collagen alpha 2(VI) which may confer cells ability to migrate on that substrate. Binds through its extracellular N- terminus growth factors, extracellular matrix proteases modulating their activity. May regulate MPP16-dependent degradation and invasion of type I collagen participating in melanoma cells invasion properties. May modulate the plasminogen system by enhancing plasminogen activation and inhibiting angiostatin. Functions also as a signal transducing protein by binding through its cytoplasmic C-terminus scaffolding and signaling proteins. May promote retraction fiber formation and cell polarization through Rho GTPase activation. May stimulate alpha-4, beta-1 integrin- mediated adhesion and spreading by recruiting and activat
Subcellular Location	Apical cell membrane {ECO:0000250}; Single- pass type I membrane protein {ECO:0000250}; Extracellular side {ECO:0000250}. Cell projection, lamellipodium membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}; Extracellular side {ECO:0000250}. Note=Localized at the apical plasma membrane it relocalizes to the lamellipodia of astrocytoma upon phosphorylation by PRKCA. Localizes to the retraction fibers. Localizes to the plasma membrane of oligodendrocytes (By similarity). {ECO:0000250}.
Tissue Specificity	Detected only in malignant melanoma cells. {ECO:0000269|PubMed:8790396}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• Cell/Tissue/Blood Products

Human CSPG4 / NG2 ELISA Kit (Sandwich ELISA) - LS-F6503 from LifeSpan Bioscience Category ELISA Kit Prices $690.00 Sizes 1 plate Sensitivity 0.056 ng/ml Range 0.156-10 ng/ml

Mouse CSPG4 / NG2 ELISA Kit (Sandwich ELISA) - LS-F11232 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity 9.38 Range 0.156-10 ng/ml

Human CSPG4 / NG2 ELISA Kit (Sandwich ELISA) - LS-F11233 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity 0.156 Range 0.156-10 ng/ml

Human MCSP ELISA Kit - abx152294 from Abbexa Category ELISA Kit Sensitivity 0.055 ng/ml Range 0.156 ng/ml - 10 ng/ml

Chondroitin sulfate proteoglycan 4 (CSPG4), Human, ELISA Kit - CSB-EL006076HU from ARP American Research Products Category ELISA Kit Prices $495.00, $695.00, $696.00, $699.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t

Chondroitin sulfate proteoglycan 4 (CSPG4), Human, ELISA Kit - E01C2110 from ARP American Research Products Category ELISA Kit Prices $535.00, $735.00 Sizes 48 t, 96 t

Chondroitin sulfate proteoglycan 4, CSPG4, Human, ELISA Kit - E2136h from ARP American Research Products Category ELISA Kit Prices $596.00 Sizes 96 t Range 0.156-10 ng/mL

Glutathione Peroxidase 4 (GPX4), Human, ELISA Kit - SEC994Hu from ARP American Research Products Category ELISA Kit Prices $720.00 Sizes 96 t Sensitivity 0.061ng/mL Range 0.156-10ng/mL

Melanoma Associated Chondroitin Sulfate Proteoglycan, MCSP, Human, ELISA Kit - E-EL-H2413 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t Sensitivity 0.094 Range 0.156-10ng/mL

Melanoma Associated Chondroitin Sulfate Proteoglycan (MCSP), Human, ELISA Kit - SEB134Hu from ARP American Research Products Category ELISA Kit Prices $685.00 Sizes 96 t Sensitivity 0.057ng/mL Range 0.156-10ng/mL

Phospholipid hydroperoxide glutathione peroxidase, mitochondrial (GPX4), Human, ELISA Kit - CSB-EL009869HU from ARP American Research Products Category ELISA Kit Prices $495.00, $695.00, $696.00, $699.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t

Melanoma Associated Chondroitin Sulfate Proteoglycan, MCSP, Rabbit, ELISA Kit - E-EL-RB2017 from ARP American Research Products Category ELISA Kit Prices $648.00 Sizes 96 t

Melanoma Associated Chondroitin Sulfate Proteoglycan, MCSP, Chicken, ELISA Kit - E-EL-Ch0014 from ARP American Research Products Category ELISA Kit Prices $445.50 Sizes 96 t

Melanoma Associated Chondroitin Sulfate Proteoglycan, MCSP, Porcine, ELISA Kit - E-EL-P0647 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Melanoma Associated Chondroitin Sulfate Proteoglycan, MCSP, Guinea Pig, ELISA Kit - E-EL-GP0029 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t

Melanoma Associated Chondroitin Sulfate Proteoglycan, MCSP, Monkey, ELISA Kit - E-EL-MK1896 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Melanoma Associated Chondroitin Sulfate Proteoglycan (MCSP), ELISA Kit - MBS2023986 from MyBioSource Category ELISA Kit Prices $355.00, $540.00, $730.00, $2,985.00, $5,410.00 Sizes 24 -strip-wells, 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity Typically less than 0.056ng/mL. Range 0.156-10ng/mL

Human MCSP(Melanoma Associated Chondroitin Sulfate Proteoglycan) ELISA Kit - E-EL-H2413 from Elabscience Category ELISA Kit Sensitivity 0.10 ng/mL Range 0.16—10 ng/mL

Human MCSP (Melanoma Associated Chondroitin Sulfate Proteoglycan) CLIA Kit - E-CL-H1415 from Elabscience Category CLIA Kit Sensitivity 18.75 pg/mL Range Average Recovery (%)

chondroitin sulfate proteoglycan 4, ELISA Kit - MBS937702 from MyBioSource Category ELISA Kit Prices $250.00, $495.00, $710.00, $2,705.00, $5,145.00 Sizes 24 -strip-wells (Limit 1), 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity The minimum detectable dose of human CSPG4 is typically less than 6.25 pg/ml. The sensitivity of this assay, or Lower Limit of Detection (LLD) was defined as the lowest protein concentration that could be differentiated from zero. It was determined the mean O.D value of 20 replicates of the zero standard added by their three standard deviations. Range 25 pg/ml -1600 pg/ml.

Chondroitin sulfate proteoglycan 4 (CSPG4), ELISA Kit - MBS7229697 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Chondroitin sulfate proteoglycan 4 (CSPG4), ELISA Kit - MBS7241480 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.1 ng/mL.

Chondroitin sulfate proteoglycan 4 (CSPG4), ELISA Kit - MBS7213838 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Chondroitin sulfate proteoglycan 4 (CSPG4), ELISA Kit - MBS7248668 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Chondroitin sulfate proteoglycan 4 (CSPG4), ELISA Kit - MBS7217184 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

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