CSPG4

Gene Symbol	CSPG4
Entrez Gene	1464
Alt Symbol	HMW-MAA, MCSP, MCSPG, MEL-CSPG, MSK16, NG2
Species	Human
Gene Type	protein-coding
Description	chondroitin sulfate proteoglycan 4
Other Description	chondroitin sulfate proteoglycan 4 (melanoma-associated)|chondroitin sulfate proteoglycan NG2|melanoma chondroitin sulfate proteoglycan|melanoma-associated chondroitin sulfate proteoglycan
Swissprots	Q6UVK1 Q92675 D3DW77
Accessions	EAW99239 EAW99240 Q6UVK1 AY359468 AAQ62842 BC033194 BC128110 AAI28111 BC172270 AAI72270 BC172576 AAI72576 BP363063 BQ679485 CA428796 CA438367 CB044012 X96753 CAA65529 NM_001897 NP_001888
Function	Proteoglycan playing a role in cell proliferation and migration which stimulates endothelial cells motility during microvascular morphogenesis. May also inhibit neurite outgrowth and growth cone collapse during axon regeneration. Cell surface receptor for collagen alpha 2(VI) which may confer cells ability to migrate on that substrate. Binds through its extracellular N- terminus growth factors, extracellular matrix proteases modulating their activity. May regulate MPP16-dependent degradation and invasion of type I collagen participating in melanoma cells invasion properties. May modulate the plasminogen system by enhancing plasminogen activation and inhibiting angiostatin. Functions also as a signal transducing protein by binding through its cytoplasmic C-terminus scaffolding and signaling proteins. May promote retraction fiber formation and cell polarization through Rho GTPase activation. May stimulate alpha-4, beta-1 integrin- mediated adhesion and spreading by recruiting and activat
Subcellular Location	Apical cell membrane {ECO:0000250}; Single- pass type I membrane protein {ECO:0000250}; Extracellular side {ECO:0000250}. Cell projection, lamellipodium membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}; Extracellular side {ECO:0000250}. Note=Localized at the apical plasma membrane it relocalizes to the lamellipodia of astrocytoma upon phosphorylation by PRKCA. Localizes to the retraction fibers. Localizes to the plasma membrane of oligodendrocytes (By similarity). {ECO:0000250}.
Tissue Specificity	Detected only in malignant melanoma cells. {ECO:0000269|PubMed:8790396}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• Cell/Tissue/Blood Products

Human NG2 peptide - ab96112 from Abcam Category Peptide

Recombinant Human NG2/MCSP/CSPG4, CF - 2585-PG-050 from R&D Systems Category Protein Source Mouse myeloma cell line, NS0-derived, Ser1583-Ser2224, with a C-terminal 6-His tag

Human MCSP Protein - abx067979 from Abbexa Category Protein Source E.coli Species Human

Human MCSP Protein - abx067981 from Abbexa Category Protein Source E.coli Species Human

MCSP - H00004184-P01-02 from Acris Antibodies Category Protein Prices $310.00 Sizes 2 µg Source in vitro transl. Species Human

Melanoma Associated Chondroitin Sulfate Proteoglycan (MCSP), Human - 20-7491 from ARP American Research Products Category Protein Prices $469.00 Sizes 50 µg Source E.coli Species Human

Melanoma Associated Chondroitin Sulfate Proteoglycan (MCSP), Human - 20-7492 from ARP American Research Products Category Protein Prices $469.00 Sizes 50 µg Source E.coli Species Human

Recombinant Melanoma Associated Chondroitin Sulfate Proteoglycan (MCSP) - RPB134Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

Recombinant Melanoma Associated Chondroitin Sulfate Proteoglycan (MCSP) - RPB134Hu02 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

Recombinant Melanoma Associated Chondroitin Sulfate Proteoglycan (MCSP) - RPB134Ra01 from Uscn Life Science Inc. Category Protein Source E.coli Species Rat

Recombinant Melanoma Associated Chondroitin Sulfate Proteoglycan (MCSP) - RPB134Ra02 from Uscn Life Science Inc. Category Protein Source E.coli Species Rat

Recombinant Glutathione Peroxidase 4 (GPX4) - RPC994Hu01 from Cloud-clone Category Protein Source E.coli Species Human

Recombinant Melanoma Associated Chondroitin Sulfate Proteoglycan (MCSP) - RPB134Hu01 from Cloud-clone Category Protein Source E.coli Species Human

Recombinant Melanoma Associated Chondroitin Sulfate Proteoglycan (MCSP) - RPB134Hu02 from Cloud-clone Category Protein Source E.coli Species Human

Recombinant Human Chondroitin sulfate proteoglycan 4(CSPG4) ,partial - CSB-YP006076HU CSB-EP006076HU CSB-BP006076HU CSB-MP006076HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

Recombinant Human NG2/MCSP/CSPG4 Protein, CF - 2585-PG from R&D Systems Category Protein Prices $329.00 Sizes 50 µg Source Mouse myeloma cell line, NS0-derived Ser1583-Ser2224, with a C-terminal 6-His tag Species Human

NG2/MCSP Recombinant Protein Antigen - NBP1-94154PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

NG2/MCSP Recombinant Protein Antigen - NBP1-89682PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

CSPG4 Peptide, Human - M34GP03727H from Creative Peptides Category Peptide Source Synthetic. Species Human

Chondroitin sulfate proteoglycan 4 (693-708) - ta-367 from Creative Peptides Category Peptide Source Homo sapiens (human)

NG2 peptide - orb13014 from Biorbyt Category Peptide Prices $170.00 Sizes 1 mg

CSPG4 Recombinant Protein (OPCD05198) - OPCD05198 from Aviva Systems Biology Category Protein Source E.coli Species Human

CSPG4 Recombinant Protein (OPCD05199) - OPCD05199 from Aviva Systems Biology Category Protein Source E.coli Species Human

NG2/MCSP Recombinant Protein Antigen - NBP2-56911PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

Chondroitin sulfate proteoglycan 4 (CSPG4), partial, Recombinant Protein - MBS1330587 from MyBioSource Category Protein Prices $1,065.00, $1,115.00, $1,240.00, $1,440.00, $1,490.00, $1,515.00, $1,570.00, $1,590.00, $1,715.00, $2,240.00, $2,245.00, $2,260.00, $2,590.00, $2,945.00 Sizes 50 µg (E-Coli), 50 µg (Yeast), 50 µg (Baculovirus), 200 µg (E-Coli), 50 µg (Mammalian-Cell), 200 µg (Yeast), 100 µg (Baculovirus), 500 µg (E-Coli), 500 µg (Yeast), 100 µg (Mammalian-Cell), 500 µg (Baculovirus), 1 mg (E-Coli), 1 mg (Yeast), 1 mg (Baculovirus) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

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