| Gene Symbol |
CSPG4
|
| Entrez Gene |
1464
|
| Alt Symbol |
HMW-MAA, MCSP, MCSPG, MEL-CSPG, MSK16, NG2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
chondroitin sulfate proteoglycan 4
|
| Other Description |
chondroitin sulfate proteoglycan 4 (melanoma-associated)|chondroitin sulfate proteoglycan NG2|melanoma chondroitin sulfate proteoglycan|melanoma-associated chondroitin sulfate proteoglycan
|
| Swissprots |
Q6UVK1 Q92675 D3DW77
|
| Accessions |
EAW99239 EAW99240 Q6UVK1 AY359468 AAQ62842 BC033194 BC128110 AAI28111 BC172270 AAI72270 BC172576 AAI72576 BP363063 BQ679485 CA428796 CA438367 CB044012 X96753 CAA65529 NM_001897 NP_001888
|
| Function |
Proteoglycan playing a role in cell proliferation and migration which stimulates endothelial cells motility during microvascular morphogenesis. May also inhibit neurite outgrowth and growth cone collapse during axon regeneration. Cell surface receptor for collagen alpha 2(VI) which may confer cells ability to migrate on that substrate. Binds through its extracellular N- terminus growth factors, extracellular matrix proteases modulating their activity. May regulate MPP16-dependent degradation and invasion of type I collagen participating in melanoma cells invasion properties. May modulate the plasminogen system by enhancing plasminogen activation and inhibiting angiostatin. Functions also as a signal transducing protein by binding through its cytoplasmic C-terminus scaffolding and signaling proteins. May promote retraction fiber formation and cell polarization through Rho GTPase activation. May stimulate alpha-4, beta-1 integrin- mediated adhesion and spreading by recruiting and activat
|
| Subcellular Location |
Apical cell membrane {ECO:0000250}; Single- pass type I membrane protein {ECO:0000250}; Extracellular side {ECO:0000250}. Cell projection, lamellipodium membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}; Extracellular side {ECO:0000250}. Note=Localized at the apical plasma membrane it relocalizes to the lamellipodia of astrocytoma upon phosphorylation by PRKCA. Localizes to the retraction fibers. Localizes to the plasma membrane of oligodendrocytes (By similarity). {ECO:0000250}.
|
| Tissue Specificity |
Detected only in malignant melanoma cells. {ECO:0000269|PubMed:8790396}.
|