RET

Gene Symbol	RET
Entrez Gene	5979
Alt Symbol	CDHF12, CDHR16, HSCR1, MEN2A, MEN2B, MTC1, PTC, RET-ELE1, RET51
Species	Human
Gene Type	protein-coding
Description	ret proto-oncogene
Other Description	RET receptor tyrosine kinase|RET transforming sequence|cadherin family member 12|cadherin-related family member 16|hydroxyaryl-protein kinase|proto-oncogene c-Ret|proto-oncogene tyrosine-protein kinase receptor Ret|rearranged during transfection|receptor tyrosine kinase|ret proto-oncogene (multiple endocrine neoplasia and medullary thyroid carcinoma 1, Hirschsprung disease)
Swissprots	P07949 Q9BTB0 A8K6Z2
Accessions	AAB47046 AAB47047 AAB50647 AAB97168 AAC50102 AAD14422 AAD14423 AAM77275 AAM77279 AAM77283 AEA76514 AEH95840 AEH95841 AGK27784 CAA75753 CAB46483 CAM91187 EAW86576 EAW86577 EAW86578 EAW86579 EAW86580 EAW86581 EAW86582 EAW86583 EAW86584 P07949 AI472270 AJ844649 AK291807 BAF84496 AK294827 BAG57939 AW297789 BC003072 AAH03072 BC004257 AAH04257 BE261914 BM661773 BM703293 BQ070075 BX332519 BX376396 DA100452 DA911581 H24956 KF421948 AGT37291 X15262 CAA33333 Y12528 CAA73131 XM_011540027 XP_011538329 NM_020630 NP_065681 NM_020975 NP_066124 NM_000323 NM_020629
Function	Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. Phosphorylates PTK2/FAK1. Regulates both cell death/survival balance and positional information. Required for the molecular mechanisms orchestration during intestine organogenesis; involved in the development of enteric nervous system and renal organogenesis during embryonic life, and promotes the formation of Peyer's patch-like structures, a major component of the gut- associated lymphoid tissue. Modulates cell adhesion via its cleavage by caspase in sympathetic neurons and mediates cell migration in an integrin (e.g. ITGB1 and ITGB3)-dependent manner. Involved in the development of the neural crest. Active in the absence of ligand, triggering apoptosis through a mechanism that requires receptor intracellular caspase cleavage. Acts as a dependence re
Subcellular Location	Cell membrane {ECO:0000269|PubMed:19823924}; Single-pass type I membrane protein {ECO:0000269|PubMed:19823924}. Endosome membrane {ECO:0000269|PubMed:19823924}; Single-pass type I membrane protein {ECO:0000269|PubMed:19823924}.
Top Pathways	Thyroid cancer, Endocytosis, Central carbon metabolism in cancer

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

PathScan ® Phospho-Ret (panTyr) Chemiluminescent Sandwich ELISA Kit - 12321 from Cell Signaling Technology Category ELISA Kit Prices $489.00 Sizes 1 kit (96 assays)

PathScan ® Phospho-Ret (panTyr) Sandwich ELISA Kit - 7034 from Cell Signaling Technology Category ELISA Kit Prices $489.00 Sizes 1 kit (96 assays)

PathScan ® Total Ret Sandwich ELISA Kit - 7032 from Cell Signaling Technology Category ELISA Kit Prices $489.00 Sizes 1 kit (96 assays)

HTScan® Ret Kinase Assay Kit - 7773 from Cell Signaling Technology Category Assay Kit

RET ELISA Kit (Competitive EIA) - LS-F6126 from LifeSpan Bioscience Category ELISA Kit Prices $700.00 Sizes 1 plate Sensitivity 52.4 ng/ml Range 123.46-10000 ng/ml

Mouse/Human/Rat Phospho-RET (Tyr1015) ELISA Kit (Cell-Based Phosphorylation ELISA) - LS-F1218 from LifeSpan Bioscience Category ELISA Kit Prices $550.00 Sizes 1 plate Range 123.46-10000 ng/ml

Mouse/Human/Rat Phospho-RET (Tyr1062) ELISA Kit (Cell-Based Phosphorylation ELISA) - LS-F1615 from LifeSpan Bioscience Category ELISA Kit Prices $550.00 Sizes 1 plate Range 123.46-10000 ng/ml

Mouse/Human/Rat RET ELISA Kit (Cell-Based ELISA) - LS-F2285 from LifeSpan Bioscience Category ELISA Kit Prices $450.00 Sizes 1 plate Range 123.46-10000 ng/ml

Phosphotyrosine RET ELISA Kit - RAB0987 from Sigma-Aldrich Category ELISA Kit Prices $637.00 Sizes 1 kt

Human Phospho-Ret DuoSet IC Economy Pack - DYC6549E from R&D Systems Category ELISA Kit

Human Phospho-Ret DuoSet IC ELISA - DYC6549-2 from R&D Systems Category ELISA Kit Prices $329.00, $649.00, $1,395.00 Sizes 1 kit (for 2 Plates), 1 kit (for 5 Plates), 1 pack (for 15 Plates) Range 62.50 - 4,000 pg/mL

Human Phospho-Ret DuoSet IC, 5 Plate - DYC6549-5 from R&D Systems Category ELISA Kit

Human Total Ret DuoSet IC ELISA, 2 Plate - DYC1168-2 from R&D Systems Category ELISA Kit Prices $329.00 Sizes 1 kit (for 2 Plates) Range 312.50 - 20,000 pg/mL

Proto-oncogene tyrosine-protein kinase receptor Ret (RET), Human, ELISA Kit - CSB-EL019572HU from ARP American Research Products Category ELISA Kit Prices $495.00, $695.00, $696.00, $699.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t

Custom Human Ret ELISA - ELH-RET from RayBiotech Category ELISA Kit Prices $615.00, $1,107.00, $2,460.00 Sizes 1 plate kit, 2 plate kit, 5 plate kit

Ret Colorimetric Cell-Based ELISA Kit - CB5605 from Assay Biotechnology Category ELISA Kit Prices $380.00, $760.00, $1,140.00 Sizes 1 kit, 2 kits, 3 kits Range > 5000 Cells

Ret (Phospho-Tyr1015) Colorimetric Cell-Based ELISA Kit - CBP1212 from Assay Biotechnology Category ELISA Kit Prices $480.00, $960.00, $1,440.00 Sizes 1 kit, 2 kits, 3 kits Range > 5000 Cells

Ret (Phospho-Tyr1062) Colorimetric Cell-Based ELISA Kit - CBP1670 from Assay Biotechnology Category ELISA Kit Prices $480.00, $960.00, $1,440.00 Sizes 1 kit, 2 kits, 3 kits Range > 5000 Cells

ret proto-oncogene, ELISA Kit - MBS905206 from MyBioSource Category ELISA Kit Prices $250.00, $495.00, $710.00, $2,705.00, $5,145.00 Sizes 24 -strip-wells (Limit 1), 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.078 ng/ml. Range 0.312 ng/ml -20 ng/ml.

Human Proto-oncogene tyrosine-protein kinase receptor Ret(RET) ELISA kit - CSB-EL019572HU from Cusabio Category ELISA Kit Sensitivity 0.078 ng/ml. Range 0.312 ng/ml-20 ng/ml

Rat RET ELISA Kit (Custom ELISA) - LS-F17779 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity To be determined Range 123.46-10000 ng/ml

Mouse RET ELISA Kit (Custom ELISA) - LS-F17780 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity To be determined Range 123.46-10000 ng/ml

Human RET ELISA Kit (Custom ELISA) - LS-F17778 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity To be determined Range 123.46-10000 ng/ml

Human Receptor Tyrosine Kinase ELISA Kit - abx053372 from Abbexa Category ELISA Kit

Proto-oncogene tyrosine-protein kinase receptor Ret, ELISA Kit - MBS288360 from MyBioSource Category ELISA Kit Prices $380.00, $500.00, $2,170.00, $3,840.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Range 0.15 ng/ml -10.0 ng/ml.

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