RET

Gene Symbol	RET
Entrez Gene	5979
Alt Symbol	CDHF12, CDHR16, HSCR1, MEN2A, MEN2B, MTC1, PTC, RET-ELE1, RET51
Species	Human
Gene Type	protein-coding
Description	ret proto-oncogene
Other Description	RET receptor tyrosine kinase|RET transforming sequence|cadherin family member 12|cadherin-related family member 16|hydroxyaryl-protein kinase|proto-oncogene c-Ret|proto-oncogene tyrosine-protein kinase receptor Ret|rearranged during transfection|receptor tyrosine kinase|ret proto-oncogene (multiple endocrine neoplasia and medullary thyroid carcinoma 1, Hirschsprung disease)
Swissprots	P07949 Q9BTB0 A8K6Z2
Accessions	AAB47046 AAB47047 AAB50647 AAB97168 AAC50102 AAD14422 AAD14423 AAM77275 AAM77279 AAM77283 AEA76514 AEH95840 AEH95841 AGK27784 CAA75753 CAB46483 CAM91187 EAW86576 EAW86577 EAW86578 EAW86579 EAW86580 EAW86581 EAW86582 EAW86583 EAW86584 P07949 AI472270 AJ844649 AK291807 BAF84496 AK294827 BAG57939 AW297789 BC003072 AAH03072 BC004257 AAH04257 BE261914 BM661773 BM703293 BQ070075 BX332519 BX376396 DA100452 DA911581 H24956 KF421948 AGT37291 X15262 CAA33333 Y12528 CAA73131 XM_011540027 XP_011538329 NM_020630 NP_065681 NM_020975 NP_066124 NM_000323 NM_020629
Function	Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. Phosphorylates PTK2/FAK1. Regulates both cell death/survival balance and positional information. Required for the molecular mechanisms orchestration during intestine organogenesis; involved in the development of enteric nervous system and renal organogenesis during embryonic life, and promotes the formation of Peyer's patch-like structures, a major component of the gut- associated lymphoid tissue. Modulates cell adhesion via its cleavage by caspase in sympathetic neurons and mediates cell migration in an integrin (e.g. ITGB1 and ITGB3)-dependent manner. Involved in the development of the neural crest. Active in the absence of ligand, triggering apoptosis through a mechanism that requires receptor intracellular caspase cleavage. Acts as a dependence re
Subcellular Location	Cell membrane {ECO:0000269|PubMed:19823924}; Single-pass type I membrane protein {ECO:0000269|PubMed:19823924}. Endosome membrane {ECO:0000269|PubMed:19823924}; Single-pass type I membrane protein {ECO:0000269|PubMed:19823924}.
Top Pathways	Thyroid cancer, Endocytosis, Central carbon metabolism in cancer

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human Ret (mutated A883 F) protein fragment - ab186459 from Abcam Category Protein Prices $521.00 Sizes 10 µg Source Baculovirus infected sf9 cells Species Human

Active human Ret (mutated E762 Q) protein fragment - ab186462 from Abcam Category Protein Prices $521.00 Sizes 10 µg Source Baculovirus infected sf9 cells Species Human

Active human Ret (mutated G691 S) protein fragment - ab186461 from Abcam Category Protein Prices $436.00 Sizes 10 µg Source Baculovirus infected sf9 cells Species Human

Active human Ret (mutated R749 T) protein fragment - ab186453 from Abcam Category Protein Prices $521.00 Sizes 10 µg Source Baculovirus infected sf9 cells Species Human

Active human Ret (mutated R813 Q) protein fragment - ab186456 from Abcam Category Protein Prices $521.00 Sizes 10 µg Source Baculovirus infected sf9 cells Species Human

Active human Ret (mutated S891 A) protein fragment - ab190381 from Abcam Category Protein Prices $521.00 Sizes 10 µg Source Baculovirus infected sf9 cells Species Human

Active human Ret (mutated V804 L) protein fragment - ab125531 from Abcam Category Protein Prices $239.00 Sizes 5 µg Source Baculovirus infected sf9 cells Species Human

Active human Ret (mutated V804 M) protein fragment - ab186463 from Abcam Category Protein Prices $521.00 Sizes 10 µg Source Baculovirus infected sf9 cells Species Human

Active human Ret protein fragment - ab84791 from Abcam Category Protein Prices $302.00, $352.00 Sizes 5 µg, 10 µg Source Baculovirus infected sf9 cells Species Human

Active human Ret protein fragment - ab54111 from Abcam Category Protein Prices $321.00 Sizes 10 µg Source Baculovirus infected sf9 cells Species Human

Human Ret full length protein - ab131828 from Abcam Category Protein Source Wheat germ Species Human

Human Ret peptide - ab49595 from Abcam Category Peptide

Human Ret protein fragment - ab152654 from Abcam Category Protein Source Wheat germ Species Human

RET Antibody Blocking Peptide - LS-E10752 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

RET Antibody Blocking Peptide - LS-E9173 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

RET Antibody Blocking Peptide - LS-E9174 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

RET Antibody Blocking Peptide - LS-E9175 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

RET Antibody Blocking Peptide - LS-E9176 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Ret Partial Recombinant Protein - H00005979-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human Ret Protein - H00005979-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

RET-Antibody-C-term-L1027-Blocking-Peptide - BP7669d from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

RET-Antibody-N-term-Q28-Blocking-Peptide - BP7669c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

RET-Antibody-C-term-T1078-Blocking-Peptide - BP7669b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

RET-Antibody-N-term-C166-Blocking-Peptide - BP7669a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Recombinant Human Ret - 1168-CR-050 from R&D Systems Category Protein Source Spodoptera frugiperda, Sf 21 (stably transfected)-derived, Leu29-Arg635, with a C-terminal 10-His tag

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