RET

Gene Symbol	RET
Entrez Gene	5979
Alt Symbol	CDHF12, CDHR16, HSCR1, MEN2A, MEN2B, MTC1, PTC, RET-ELE1, RET51
Species	Human
Gene Type	protein-coding
Description	ret proto-oncogene
Other Description	RET receptor tyrosine kinase|RET transforming sequence|cadherin family member 12|cadherin-related family member 16|hydroxyaryl-protein kinase|proto-oncogene c-Ret|proto-oncogene tyrosine-protein kinase receptor Ret|rearranged during transfection|receptor tyrosine kinase|ret proto-oncogene (multiple endocrine neoplasia and medullary thyroid carcinoma 1, Hirschsprung disease)
Swissprots	P07949 Q9BTB0 A8K6Z2
Accessions	AAB47046 AAB47047 AAB50647 AAB97168 AAC50102 AAD14422 AAD14423 AAM77275 AAM77279 AAM77283 AEA76514 AEH95840 AEH95841 AGK27784 CAA75753 CAB46483 CAM91187 EAW86576 EAW86577 EAW86578 EAW86579 EAW86580 EAW86581 EAW86582 EAW86583 EAW86584 P07949 AI472270 AJ844649 AK291807 BAF84496 AK294827 BAG57939 AW297789 BC003072 AAH03072 BC004257 AAH04257 BE261914 BM661773 BM703293 BQ070075 BX332519 BX376396 DA100452 DA911581 H24956 KF421948 AGT37291 X15262 CAA33333 Y12528 CAA73131 XM_011540027 XP_011538329 NM_020630 NP_065681 NM_020975 NP_066124 NM_000323 NM_020629
Function	Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. Phosphorylates PTK2/FAK1. Regulates both cell death/survival balance and positional information. Required for the molecular mechanisms orchestration during intestine organogenesis; involved in the development of enteric nervous system and renal organogenesis during embryonic life, and promotes the formation of Peyer's patch-like structures, a major component of the gut- associated lymphoid tissue. Modulates cell adhesion via its cleavage by caspase in sympathetic neurons and mediates cell migration in an integrin (e.g. ITGB1 and ITGB3)-dependent manner. Involved in the development of the neural crest. Active in the absence of ligand, triggering apoptosis through a mechanism that requires receptor intracellular caspase cleavage. Acts as a dependence re
Subcellular Location	Cell membrane {ECO:0000269|PubMed:19823924}; Single-pass type I membrane protein {ECO:0000269|PubMed:19823924}. Endosome membrane {ECO:0000269|PubMed:19823924}; Single-pass type I membrane protein {ECO:0000269|PubMed:19823924}.
Top Pathways	Thyroid cancer, Endocytosis, Central carbon metabolism in cancer

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Ret CRISPR/Cas9 KO Plasmid (h) - sc-400311 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Ret HDR Plasmid (h) - sc-400311-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Ret Double Nickase Plasmid (h) - sc-400311-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Ret Double Nickase Plasmid (h2) - sc-400311-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Ret CRISPR Activation Plasmid (h) - sc-400311-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Ret CRISPR Activation Plasmid (h2) - sc-400311-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Ret Lentiviral Activation Particles (h) - sc-400311-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Ret Lentiviral Activation Particles (h2) - sc-400311-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Ret siRNA (h) - sc-36404 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Ret shRNA Plasmid (h) - sc-36404-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Ret shRNA (h) Lentiviral Particles - sc-36404-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Ret RNAi - H00005979-R08 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

MISSION® esiRNA - EHU161031 from Sigma-Aldrich Category siRNA Prices $250.00 Sizes 50 µg

MISSION® siRNA - SIHK1944 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

MISSION® siRNA - SIHK1945 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

MISSION® siRNA - SIHK1946 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

CompoZr® Knockout ZFN Kit - CKOZFN1064 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit - CKOZFN1298 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1298 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1064 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR12832 from Sigma-Aldrich Category miRNA Prices $350.00 Sizes hutr12832

RET siRNA (Human) - CRH4047 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

Ret RNAi - H00005979-R07 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

RET - MBS8212391 from MyBioSource Prices $365.00, $515.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

shRNA set against Human RET (NM_020630.4) - SHH392044 from Creative biogene Category siRNA Species Reactivities Human

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