Gene Symbol | RET |
---|---|
Entrez Gene | 5979 |
Alt Symbol | CDHF12, CDHR16, HSCR1, MEN2A, MEN2B, MTC1, PTC, RET-ELE1, RET51 |
Species | Human |
Gene Type | protein-coding |
Description | ret proto-oncogene |
Other Description | RET receptor tyrosine kinase|RET transforming sequence|cadherin family member 12|cadherin-related family member 16|hydroxyaryl-protein kinase|proto-oncogene c-Ret|proto-oncogene tyrosine-protein kinase receptor Ret|rearranged during transfection|receptor tyrosine kinase|ret proto-oncogene (multiple endocrine neoplasia and medullary thyroid carcinoma 1, Hirschsprung disease) |
Swissprots | P07949 Q9BTB0 A8K6Z2 |
Accessions | AAB47046 AAB47047 AAB50647 AAB97168 AAC50102 AAD14422 AAD14423 AAM77275 AAM77279 AAM77283 AEA76514 AEH95840 AEH95841 AGK27784 CAA75753 CAB46483 CAM91187 EAW86576 EAW86577 EAW86578 EAW86579 EAW86580 EAW86581 EAW86582 EAW86583 EAW86584 P07949 AI472270 AJ844649 AK291807 BAF84496 AK294827 BAG57939 AW297789 BC003072 AAH03072 BC004257 AAH04257 BE261914 BM661773 BM703293 BQ070075 BX332519 BX376396 DA100452 DA911581 H24956 KF421948 AGT37291 X15262 CAA33333 Y12528 CAA73131 XM_011540027 XP_011538329 NM_020630 NP_065681 NM_020975 NP_066124 NM_000323 NM_020629 |
Function | Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. Phosphorylates PTK2/FAK1. Regulates both cell death/survival balance and positional information. Required for the molecular mechanisms orchestration during intestine organogenesis; involved in the development of enteric nervous system and renal organogenesis during embryonic life, and promotes the formation of Peyer's patch-like structures, a major component of the gut- associated lymphoid tissue. Modulates cell adhesion via its cleavage by caspase in sympathetic neurons and mediates cell migration in an integrin (e.g. ITGB1 and ITGB3)-dependent manner. Involved in the development of the neural crest. Active in the absence of ligand, triggering apoptosis through a mechanism that requires receptor intracellular caspase cleavage. Acts as a dependence re |
Subcellular Location | Cell membrane {ECO:0000269|PubMed:19823924}; Single-pass type I membrane protein {ECO:0000269|PubMed:19823924}. Endosome membrane {ECO:0000269|PubMed:19823924}; Single-pass type I membrane protein {ECO:0000269|PubMed:19823924}. |
Top Pathways | Thyroid cancer, Endocytosis, Central carbon metabolism in cancer |
Phospho-Ret (Tyr905) Antibody - 3221 from Cell Signaling Technology
|
||||||||||
Ret (E1N8X) XP ® Rabbit mAb - 14556 from Cell Signaling Technology
|
||||||||||
Ret (D3D8R) Rabbit mAb - 14698 from Cell Signaling Technology
|
||||||||||
Ret Antibody - 3220 from Cell Signaling Technology
|
||||||||||
Ret (E1N9A) Rabbit mAb (Flow Preferred) - 14699 from Cell Signaling Technology
|
||||||||||
Ret (C31B4) Rabbit mAb - 3223 from Cell Signaling Technology
|
||||||||||
Ret (C-20) - sc-1290 from Santa Cruz Biotechnology
|
||||||||||
Ret (C-3) - sc-365943 from Santa Cruz Biotechnology
|
||||||||||
Ret (H-300) - sc-13104 from Santa Cruz Biotechnology
|
||||||||||
Ret (8D10C9) - sc-101422 from Santa Cruz Biotechnology
|
||||||||||
Ret (C-19) - sc-167 from Santa Cruz Biotechnology
|
||||||||||
Ret (6E4C4) - sc-101423 from Santa Cruz Biotechnology
|
||||||||||
Anti-Ret (phospho Y1015) antibody - ab74154 from Abcam
|
||||||||||
Anti-Ret (phospho Y1062) antibody - ab123544 from Abcam
|
||||||||||
Anti-Ret (phospho Y1062) antibody - ab51103 from Abcam
|
||||||||||
Anti-Ret antibody - ab51122 from Abcam
|
||||||||||
Anti-Ret antibody - ab133710 from Abcam
|
||||||||||
Anti-Ret antibody - ab49596 from Abcam
|
||||||||||
Anti-Ret antibody - ab184189 from Abcam
|
||||||||||
Anti-Ret antibody [10F12] - ab196528 from Abcam
|
||||||||||
Anti-Ret antibody [8D10C9] - ab128061 from Abcam
|
||||||||||
Anti-Ret antibody [EPR2871] - ab134100 from Abcam
|
||||||||||
Anti-Ret antibody [MM0529-10F12] - ab90119 from Abcam
|
||||||||||
Anti-Ret antibody [RET01] - ab1840 from Abcam
|
||||||||||
Anti-Ret antibody [RM-0050-4G1] - ab73253 from Abcam
|