RET

Gene Symbol RET
Entrez Gene 5979
Alt Symbol CDHF12, CDHR16, HSCR1, MEN2A, MEN2B, MTC1, PTC, RET-ELE1, RET51
Species Human
Gene Type protein-coding
Description ret proto-oncogene
Other Description RET receptor tyrosine kinase|RET transforming sequence|cadherin family member 12|cadherin-related family member 16|hydroxyaryl-protein kinase|proto-oncogene c-Ret|proto-oncogene tyrosine-protein kinase receptor Ret|rearranged during transfection|receptor tyrosine kinase|ret proto-oncogene (multiple endocrine neoplasia and medullary thyroid carcinoma 1, Hirschsprung disease)
Swissprots P07949 Q9BTB0 A8K6Z2
Accessions AAB47046 AAB47047 AAB50647 AAB97168 AAC50102 AAD14422 AAD14423 AAM77275 AAM77279 AAM77283 AEA76514 AEH95840 AEH95841 AGK27784 CAA75753 CAB46483 CAM91187 EAW86576 EAW86577 EAW86578 EAW86579 EAW86580 EAW86581 EAW86582 EAW86583 EAW86584 P07949 AI472270 AJ844649 AK291807 BAF84496 AK294827 BAG57939 AW297789 BC003072 AAH03072 BC004257 AAH04257 BE261914 BM661773 BM703293 BQ070075 BX332519 BX376396 DA100452 DA911581 H24956 KF421948 AGT37291 X15262 CAA33333 Y12528 CAA73131 XM_011540027 XP_011538329 NM_020630 NP_065681 NM_020975 NP_066124 NM_000323 NM_020629
Function Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. Phosphorylates PTK2/FAK1. Regulates both cell death/survival balance and positional information. Required for the molecular mechanisms orchestration during intestine organogenesis; involved in the development of enteric nervous system and renal organogenesis during embryonic life, and promotes the formation of Peyer's patch-like structures, a major component of the gut- associated lymphoid tissue. Modulates cell adhesion via its cleavage by caspase in sympathetic neurons and mediates cell migration in an integrin (e.g. ITGB1 and ITGB3)-dependent manner. Involved in the development of the neural crest. Active in the absence of ligand, triggering apoptosis through a mechanism that requires receptor intracellular caspase cleavage. Acts as a dependence re
Subcellular Location Cell membrane {ECO:0000269|PubMed:19823924}; Single-pass type I membrane protein {ECO:0000269|PubMed:19823924}. Endosome membrane {ECO:0000269|PubMed:19823924}; Single-pass type I membrane protein {ECO:0000269|PubMed:19823924}.
Top Pathways Thyroid cancer, Endocytosis, Central carbon metabolism in cancer

Phospho-Ret (Tyr905) Antibody - 3221 from Cell Signaling Technology

Prices $287.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of recombinant human GST-Ret (His658-Asp1110) and extracts from the TT human medullary thyroid carcinoma cell line using Phospho-Ret (Tyr905) Antibody.

Ret (E1N8X) XP ® Rabbit mAb - 14556 from Cell Signaling Technology

Prices $109.00, $282.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone E1N8X
Western blot analysis of extracts from various cell lines using Ret (E1N8X) XP ® Rabbit mAb (upper) and β-Actin (D6A8) Rabbit mAb #8457 (lower).

Ret (D3D8R) Rabbit mAb - 14698 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D3D8R
Western blot analysis of extracts from various cell lines using Ret (D3D8R) Rabbit mAb (upper) and β-Actin (D6A8) Rabbit mAb #8457 (lower).

Ret Antibody - 3220 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from TT cells using Ret Antibody.

Ret (E1N9A) Rabbit mAb (Flow Preferred) - 14699 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (400 tests)
Host Rabbit
Clonality Monoclonal
Clone E1N9A
Western blot analysis of extracts from various cell lines using Ret (E1N9A) (Flow Preferred) Rabbit mAb (upper) and β-Actin (D6A8) Rabbit mAb #8457 (lower).

Ret (C31B4) Rabbit mAb - 3223 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone C31B4
Western blot analysis of extracts from TT cells using Ret (C31B4) Rabbit mAb.

Ret (C-20) - sc-1290 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Western blot analysis of Ret expression in Ret (long) (A,C) and Ret (short) (B,D) transfected NIH/3T3 cells. Antibodies tested include Ret (C-20): sc-1290 (A,B) and Ret (C-19): sc-167 (C,D).

Ret (C-3) - sc-365943 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Ret (C-3): sc-365943. Western blot analysis of Ret expression in non-transfected: sc-117752 (A) and human Ret transfected: sc-158925 (B) 293T whole cell lysates.

Ret (H-300) - sc-13104 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Ret (H-300): sc-13104. Western blot analysis of Ret expression in a Ret transfected whole cell lysate.

Ret (8D10C9) - sc-101422 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Ret (8D10C9): sc-101422. Western blot analysis of human truncated recombinant Ret fusion protein.

Ret (C-19) - sc-167 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Ret (C-19): sc-167. Immunofluorescence staining of methanol-fixed K-562 cells showing membrane localization.

Ret (6E4C4) - sc-101423 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Ret (6E4C4): sc-101423. Western blot analysis of human truncated recombinant Ret fusion protein.

Anti-Ret (phospho Y1015) antibody - ab74154 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Ret (phospho Y1015) antibody (ab74154) at 1/500 dilutionLane 1 : Extracts from COS7 cells treated with EGF (200ng/ml, 30mins)Lane 2 : Extracts from COS7 cells treated with EGF (200ng/ml, 30mins) with immunising peptide at 10 µgLysates/proteins at 30 µg per lane.

Anti-Ret (phospho Y1062) antibody - ab123544 from Abcam

Prices $384.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Ret (phospho Y1062) antibody (ab123544) at 1 µg/mlLane 1 : K562 (Human erythromyeloblastoid leukemia cell line) Whole Cell LysateLane 2 : K562 (Human erythromyeloblastoid leukemia cell line) Whole Cell Lysate with Immunising peptide at 1 µg/mlLane 3 : K562 (Human erythromyeloblastoid leukemia cell line) Whole Cell Lysate with Control peptide at 1 µg/mlLysates/proteins at 25 µg per lane.SecondaryGoat Anti-Rabbit IgG H&L (HRP) preadsorbed (ab97080) at 1/5000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.

Anti-Ret (phospho Y1062) antibody - ab51103 from Abcam

Prices $379.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Ret (phospho Y1062) antibody (ab51103) at 1/500 dilutionLane 1 : K562 cell lysate.Lane 2 : K562 cell Lysate. For this panel, ab51103 was pre-incubated with immunizing peptide.

Anti-Ret antibody - ab51122 from Abcam

Prices $384.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Ret antibody (ab51122) at 1/500 dilutionLane 1 : K562 LysateLane 2 : K562 Lysate. For this panel ab51122 was pre-incubated with the immunizing peptide.

Anti-Ret antibody - ab133710 from Abcam

Prices $378.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human brain cerebellum tissue labelling Ret with ab133710 at 10 µg/ml, followed by biotinylated goat anti-rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.

Anti-Ret antibody - ab49596 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Ret antibody (ab49596) at 1 µg/mlLane 1 : LoVo (Human colon adenocarcinoma cell line) Nuclear Lysate (ab14859)Lane 2 : K562 (Human erythromyeloblastoid leukemia cell line) Whole Cell Lysate - tumor cell line (ab29306)Lysates/proteins at 10 µg per lane.SecondaryGoat polyclonal to Rabbit IgG - H&L - Pre-Adsorbed (HRP) at 1/3000 dilutionPerformed under reducing conditions.

Anti-Ret antibody - ab184189 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Ret antibody (ab184189) at 1/1000 dilutionLane 1 : U87-MG whole cell lysateLane 2 : SK N SH whole cell lysateLane 3 : IMR32 whole cell lysateLane 4 : SK-N-AS whole cell lysateLysates/proteins at 30 µg per lane.

Anti-Ret antibody [10F12] - ab196528 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone 10F12

Anti-Ret antibody [8D10C9] - ab128061 from Abcam

Prices $378.00
Sizes 50 µl
Host Mouse
Clonality Monoclonal
Clone 8D10C9
All lanes : Anti-Ret antibody [8D10C9] (ab128061)Lane 1 : truncated tagged Ret recombinant proteinLane 2 : Ret (amino acids 658-1063)/hIgGFc transfected CHO-K1 cell lysate

Anti-Ret antibody [EPR2871] - ab134100 from Abcam

Prices $391.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR2871
All lanes : Anti-Ret antibody [EPR2871] (ab134100) at 1/10000 dilutionLane 1 : Neuro-2a cell lysateLane 2 : TT cell lysateLysates/proteins at 10 µg per lane.SecondaryHRP labelled goat anti-rabbit at 1/2000 dilution

Anti-Ret antibody [MM0529-10F12] - ab90119 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone MM0529-10F12
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human placental tissue section (4µm) labelling Ret with ab90119. Tissue was treated with 15µg/ml Protenase K for antigen retrieval and fixed with 4% PFA. A HRP-conjugated anti-mouse IgG was used as the secondary antibody (30 minutes at room temperature) followed by DAB color development.

Anti-Ret antibody [RET01] - ab1840 from Abcam

Prices $378.00
Sizes 500 µl
Host Mouse
Clonality Monoclonal
Clone RET01
ab1840 - immunohistochemistry

Anti-Ret antibody [RM-0050-4G1] - ab73253 from Abcam

Prices $370.00
Sizes 100 µg
Host Rat
Clonality Monoclonal
Clone RM-0050-4G1
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